Document Detail

Effect of increased surface tension and assisted ventilation on 99mTc-DTPA clearance.
MedLine Citation:
PMID:  2453499     Owner:  NLM     Status:  MEDLINE    
Experiments were performed to determine the effects of conventional mechanical ventilation (CMV) and high-frequency oscillation (HFO) on the clearance of technetium-99m-labeled diethylenetriamine pentaacetate (99mTc-DTPA) from lungs with altered surface tension properties. A submicronic aerosol of 99mTc-DTPA was insufflated into the lungs of anesthetized, tracheotomized rabbits before and 1 h after the administration of the aerosolized detergent dioctyl sodium sulfosuccinate (OT). Rabbits were ventilated by one of four methods: 1) spontaneous breathing; 2) CMV at 12 cmH2O mean airway pressure (MAP); 3) HFO at 12 cmH2O MAP; 4) HFO at 16 cmH2O MAP. Administration of OT resulted in decreased arterial PO2 (PaO2), increased lung wet-to-dry weight ratios, and abnormal lung pressure-volume relationships, compatible with increased surface tension. 99mTc-DTPA clearance was accelerated after OT in all groups. The post-OT rate of clearance (k) was significantly faster (P less than 0.05) in the CMV at 12 cmH2O MAP [k = 7.57 +/- 0.71%/min (SE)] and HFO at 16 cmH2O MAP (k = 6.92 +/- 0.61%/min) groups than in the spontaneously breathing (k = 4.32 +/- 0.55%/min) and HFO at 12 cmH2O MAP (4.68 +/- 0.63%/min) groups. The clearance curves were biexponential in the former two groups. We conclude that pulmonary clearance of 99mTc-DTPA is accelerated in high surface tension pulmonary edema, and this effect is enhanced by both conventional ventilation and HFO at high mean airway pressure.
A L Jefferies; T Kawano; S Mori; R Burger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  64     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-06-27     Completed Date:  1988-06-27     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  562-8     Citation Subset:  IM    
Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada.
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MeSH Terms
Dioctyl Sulfosuccinic Acid / pharmacology
Lung / drug effects,  physiology*
Organometallic Compounds / diagnostic use*
Pentetic Acid / diagnostic use*
Respiration, Artificial*
Surface Tension
Technetium / diagnostic use*
Technetium Tc 99m Pentetate
Reg. No./Substance:
0/Organometallic Compounds; 10041-19-7/Dioctyl Sulfosuccinic Acid; 65454-61-7/Technetium Tc 99m Pentetate; 67-43-6/Pentetic Acid; 7440-26-8/Technetium

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