| Effect of increased pump flow on hepatic blood flow and systemic inflammatory response following on-pump coronary artery bypass grafting. | |
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MedLine Citation:
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PMID: 20861205 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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METHODS: Ethics committee approval was obtained. Twelve consecutive patients with good or moderate left ventricular function undergoing elective or inpatient coronary artery bypass grafting were included in the study after obtaining informed consent. Patients were randomised to receive either normal flow or higher pump flow (20% more than the usual flow during hypothermia). Hepatic blood flow, cytokines such as interleukins 1β, 6, 8, 10 and 12, tumour necrosis factor-α and complements C3a, C4a and C5a were measured during the peri-operative period. Data were analysed using SPSS (ver.15). Categorical data were compared using the chi-square test and trends in cytokines were compared using a repeated measures ANOVA test. RESULTS: Both the groups were similar in pre- and peri-operative variables. Hepatic blood flow almost doubled in the high-pump-flow group following an increase in the flow rate during hypothermia(p=0.026). The release of serum complement IL-6 and 8 appeared to be reduced in the high-flow group; however, the difference did not reach statistical significance. CONCLUSIONS: Higher pump flows during hypothermic CPB increase hepatic blood flow. There was a trend towards attenuation of post-operative inflammatory response; however, larger studies will be needed to confirm these findings. |
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Authors:
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Rajeshwara Krishna Prasad Adluri; Arvind V Singh; Julian Skoyles; Tony Hitch; Adrian Robins; Mya Baker; Ian M Mitchell |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Perfusion Volume: 25 ISSN: 1477-111X ISO Abbreviation: Perfusion Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-23 Completed Date: 2011-02-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8700166 Medline TA: Perfusion Country: England |
Other Details:
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Languages: eng Pagination: 293-303 Citation Subset: IM |
Affiliation:
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Department of Cardiac Surgery, Trent Cardiac Centre, Nottingham City Hospital, Nottingham, UK. arkrishnap@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Complement System Proteins
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analysis Coronary Artery Bypass / adverse effects*, methods Cytokines / blood Heart-Assist Devices / adverse effects* Inflammation / etiology* Liver / blood supply* Perioperative Period Regional Blood Flow* Tumor Necrosis Factor-alpha / blood |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Tumor Necrosis Factor-alpha; 9007-36-7/Complement System Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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