| Effect of increased intra-abdominal pressure on urinary system development in fetal rabbits. | |
| | |
MedLine Citation:
|
PMID: 22099478 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
AIM: To investigate the effect of increased intra-abdominal pressure (IAP) on the fetal urinary system. MATERIALS AND METHODS: Pregnant rabbits (15-day gestation) were used. Control (n = 5) and experimental (EG, n = 4) groups underwent intraperitoneal catheter placement. The IAP was increased by intraperitoneal air insufflations during the third trimester in the EG. At term, organ weight and organ weight/body weight (BW) ratios were noted, histological examination of the urinary system organs was performed, and the apoptotic indexes were calculated. RESULTS: BW and total renal weight were significantly increased in the EG (38.65 ± 8.34 g vs 49.36 ± 8.81 g, p = 0.008; and 0.406 ± 0.132 g vs 0.531 ± 0.129 g, p = 0.02). Total renal weight/BW ratio did not differ between groups (0.0103 ± 0.001 vs 0.0107 ± 0.001; p = 0.33). Bladder weight and bladder weight/BW ratio was also significantly increased in the EG (0.067 ± 0.014 g vs 0.114 ± 0.026 g, p = 0.00; and 0.00175 ± 0.00026 vs 0.00229 ± 0.00036, p = 0.001). Immature glomeruli and collecting tubules, and a thin and underdeveloped muscular layer in the ureter and bladder were encountered in the EG, and the apoptotic cell index was significantly increased (p < 0.05). CONCLUSION: Increased IAP has an adverse effect on fetal urinary system development, and may play a role in the pathogenesis of various congenital abnormalities of the urinary system. |
| | |
Authors:
|
Ibrahim Karnak; Pergin Atilla; Sevda Müftüoğlu |
Related Documents
:
|
21640688 - Translation of hypertension treatment guidelines into practice: a review of implementat... 1124538 - Toxicity of aerosol propellants in the respiratory and circulatory systems. viii. respi... 3996788 - Body position and acoustic admittance. 1107768 - Massive air embolism in a neonate with respiratory distress. 2917448 - Compartment syndromes of the lower leg. 21399508 - Effects of treatment with β-blocker and aldosterone antagonist on central and peripher... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-16 |
Journal Detail:
|
Title: Journal of pediatric urology Volume: - ISSN: 1873-4898 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101233150 Medline TA: J Pediatr Urol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
|
Hacettepe University Faculty of Medicine, Departments of Pediatric Surgery, 06100 Sıhhiye, Ankara, Turkey. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Tamsulosin for the management of distal ureteral stones in children: A prospective randomized study.
Next Document: Religiousness, mental health, and quality of life in Brazilian dialysis patients.