| Effect of increased free fatty acids on myocardial oxygen extraction and angina threshold during atrial pacing. | |
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MedLine Citation:
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PMID: 872327 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To evaluate whether elevated arterial free fatty acids (FFA) increase myocardial oxygen demand and ischemia, 15 fasting patients with coronary artery disease underwent a standardized atrial pacing test before (PTI) and during (PT2) heparin infusion. The patients were monitored for clinical and electrocardiographic (ECG) manifestations of ischemia. Myocardial extraction of lactate, inorganic phosphate, oxygen and FFA was measured before and during each PT. The control arterial FFA was 0.65 +/- 0.03 micromole/ml and rose to 1.83 +/- 0.16 micromole/ml during heparin influsion. Myocardial oxygen extraction at rest and during PT was not affected by the increase in arterial FFA. Seven patients asymptomatic during PT1 did not develop ischaemic manifestations during PT2. In eight patients with angina during both PTs, increased arterial FFA concentration did not modify the severity of anginal pain, the amount of ST-segment depression and the myocardial balance of lactate or inorganic phosphate. Elevation of arterial FFA by heparin neither increased myocardial oxygen extraction at rest or during pacing nor accentuated ischemic manifestations during PT. |
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Authors:
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G R Dagenais; B Jalbert |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Circulation Volume: 56 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1977 Aug |
Date Detail:
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Created Date: 1977-09-02 Completed Date: 1977-09-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 315-9 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Angina Pectoris / blood, metabolism*, physiopathology Blood Pressure Electrocardiography Fatty Acids, Nonesterified / blood, pharmacology* Female Heart Rate Heparin / pharmacology Humans Lactates / blood Male Middle Aged Myocardium / metabolism* Oxygen / blood Oxygen Consumption* Pacemaker, Artificial* Phosphates / blood |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Nonesterified; 0/Lactates; 0/Phosphates; 7782-44-7/Oxygen; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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