Document Detail

Effect of increased free fatty acids on myocardial oxygen extraction and angina threshold during atrial pacing.
MedLine Citation:
PMID:  872327     Owner:  NLM     Status:  MEDLINE    
To evaluate whether elevated arterial free fatty acids (FFA) increase myocardial oxygen demand and ischemia, 15 fasting patients with coronary artery disease underwent a standardized atrial pacing test before (PTI) and during (PT2) heparin infusion. The patients were monitored for clinical and electrocardiographic (ECG) manifestations of ischemia. Myocardial extraction of lactate, inorganic phosphate, oxygen and FFA was measured before and during each PT. The control arterial FFA was 0.65 +/- 0.03 micromole/ml and rose to 1.83 +/- 0.16 micromole/ml during heparin influsion. Myocardial oxygen extraction at rest and during PT was not affected by the increase in arterial FFA. Seven patients asymptomatic during PT1 did not develop ischaemic manifestations during PT2. In eight patients with angina during both PTs, increased arterial FFA concentration did not modify the severity of anginal pain, the amount of ST-segment depression and the myocardial balance of lactate or inorganic phosphate. Elevation of arterial FFA by heparin neither increased myocardial oxygen extraction at rest or during pacing nor accentuated ischemic manifestations during PT.
G R Dagenais; B Jalbert
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation     Volume:  56     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1977 Aug 
Date Detail:
Created Date:  1977-09-02     Completed Date:  1977-09-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  315-9     Citation Subset:  AIM; IM    
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MeSH Terms
Angina Pectoris / blood,  metabolism*,  physiopathology
Blood Pressure
Fatty Acids, Nonesterified / blood,  pharmacology*
Heart Rate
Heparin / pharmacology
Lactates / blood
Middle Aged
Myocardium / metabolism*
Oxygen / blood
Oxygen Consumption*
Pacemaker, Artificial*
Phosphates / blood
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 0/Lactates; 0/Phosphates; 7782-44-7/Oxygen; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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