Document Detail


Effect of immunotherapy on sCD23 levels in patients allergic to Hymenoptera venom.
MedLine Citation:
PMID:  8885804     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: sCD23 is the designation given to the low affinity IgE receptor. The soluble fragment of this receptor (sCD23) participates in the regulation of IgE synthesis. OBJECTIVE: The purpose of this study is to examine the effect of a venom immunotherapy regimen on sCD23 levels. METHODS: We measured sCD23 levels by ELISA in Hymenoptera venom-allergic patients (positive skin tests and a history of systemic reactions to Hymenoptera sting) in serial sera collected over a course of venom immunotherapy with a mean duration of 54 months. Mean pre-sCD23 and post-sCD23 levels were compared using a Student's two-tailed t test. RESULTS: sCD23 levels were found to be unchanged over the course of venom immunotherapy. CONCLUSIONS: This is the first longitudinal study that has been done. It suggests that while both immunotherapy and sCD23 are known to be involved in the regulations of IgE synthesis in the atopic patient, the immunomodulation seen in venom immunotherapy is not mediated through sCD23 in any simple regulatory manner.
Authors:
S O Forman; M M Reddy; D S Mazza; D K Meriney; M H Grieco
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology     Volume:  77     ISSN:  1081-1206     ISO Abbreviation:  Ann. Allergy Asthma Immunol.     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1996-11-20     Completed Date:  1996-11-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9503580     Medline TA:  Ann Allergy Asthma Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  282-4     Citation Subset:  IM    
Affiliation:
R A Cooke Institute of Allergy, St. Luke's-Roosevelt Hospital Center, Columbia, University College of Physicians & Surgeons, New York, New York, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Animals
Arthropod Venoms / immunology*
Child
Enzyme-Linked Immunosorbent Assay
Female
Humans
Hymenoptera*
Hypersensitivity / blood,  diagnosis,  therapy*
Immunotherapy*
Male
Middle Aged
Receptors, IgE / blood*
Skin Tests
Time Factors
Chemical
Reg. No./Substance:
0/Arthropod Venoms; 0/Receptors, IgE

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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