Document Detail

Effect of imipramine on linear and nonlinear measures of heart rate variability in children.
MedLine Citation:
PMID:  14598002     Owner:  NLM     Status:  MEDLINE    
We investigated the effects of treatment with the tricyclic antidepressant (TCA) imipramine in eight children in supine and standing postures. We used 256 seconds of real-time data for the analyses. Spectral analysis showed a significant decrease of high-frequency (HF) power (0.15-0.5 Hz), especially in the standing posture. Low frequency (LF) HF ratios were significantly higher in the standing posture after treatment, suggesting increased sympathovagal interaction. We also obtained the nonlinear measures of fractal dimension (FD), and approximate entropy (APEN). Although the FD of heart rate was significantly lower in the standing posture, APEN was significantly decreased after treatment in either posture and was the most sensitive measure in this study. These findings suggest a decreased cardiac vagal function with a relative increase in sympathetic responsiveness, which may in part be related to the cardiotoxicity of these drugs. These findings are discussed in relation to the cardiovascular side effects of TCAs.
K Srinivasan; M V Ashok; M Vaz; V K Yeragani
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-11-07
Journal Detail:
Title:  Pediatric cardiology     Volume:  25     ISSN:  0172-0643     ISO Abbreviation:  Pediatr Cardiol     Publication Date:    2004 Jan-Feb
Date Detail:
Created Date:  2004-03-24     Completed Date:  2004-04-22     Revised Date:  2008-02-20    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  20-5     Citation Subset:  IM    
Department of Psychiatry, St. John's Medical College Hospital, Sarjapur Road, Bangalore 560034, India.
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MeSH Terms
Antidepressive Agents, Tricyclic / pharmacology*
Enuresis / physiopathology
Heart Rate / drug effects*
Imipramine / pharmacology*
Linear Models
Nonlinear Dynamics
Posture / physiology
Supine Position / physiology
Reg. No./Substance:
0/Antidepressive Agents, Tricyclic; 50-49-7/Imipramine

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