Document Detail


Effect of ibuprofen on bilirubin-albumin binding affinity in premature infants.
MedLine Citation:
PMID:  20954849     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To evaluate the effect of ibuprofen on bilirubin-albumin binding affinity and unbound bilirubin in premature infants.
STUDY DESIGN: A prospective study with subjects serving as their own controls was performed on <30 weeks' gestational age infants with unconjugated hyperbilirubinemia and who received ibuprofen for patent ductus arteriosus. Infants with congenital malformation, TORCH infections, and conjugated hyperbilirubinemia were excluded. Total serum bilirubin (TSB) and unbound bilirubin (modified peroxidase test) were measured prior to (baseline) and after (follow-up) initiation of ibuprofen. The bilirubin/albumin equilibrium association binding constant was calculated using albumin, TSB, and unbound bilirubin.
RESULTS: Ten infants were studied. The mean TSB between baseline (5.9±1.7 mg/dL) was higher than that at follow-up [4.9±1.7 mg/dL]. Mean unbound bilirubin at baseline (0.75±0.65 μg/dL) was similar to that at follow-up (0.63±0.46 μg/dL). No difference existed between mean baseline binding constant (49±50 L/μmol) and that at follow-up (44±36 L/μmol). The ratio of unbound bilirubin with and without ibuprofen, index of displacing effect, was 0.88 (95% CI 0.63-1.14).
CONCLUSIONS: Ibuprofen may not be associated with bilirubin displacing effect in relatively stable premature infants with mild to moderate unconjugated hyperbilirubinemia.
Authors:
Sanjiv B Amin; Nicholas Miravalle
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-10-18
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  39     ISSN:  1619-3997     ISO Abbreviation:  J Perinat Med     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-13     Completed Date:  2011-05-23     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  55-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Albumins / metabolism*
Bilirubin / blood*
Cyclooxygenase Inhibitors / pharmacology*,  therapeutic use
Ductus Arteriosus, Patent / drug therapy
Female
Humans
Hyperbilirubinemia / blood*
Ibuprofen / analogs & derivatives*,  pharmacology,  therapeutic use
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / drug therapy
Lysine / analogs & derivatives*,  pharmacology,  therapeutic use
Male
Prospective Studies
Grant Support
ID/Acronym/Agency:
DC 6229-04/DC/NIDCD NIH HHS; K23 DC006229/DC/NIDCD NIH HHS; K23 DC006229-06/DC/NIDCD NIH HHS; UL1 RR 024160/RR/NCRR NIH HHS; UL1 RR024160/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Albumins; 0/Cyclooxygenase Inhibitors; K3Z4F929H6/Lysine; N01ORX9D6S/solufenum; RFM9X3LJ49/Bilirubin; WK2XYI10QM/Ibuprofen
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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