Document Detail


Effect of ibopamine on peripheral haemodynamics.
MedLine Citation:
PMID:  6873134     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Peripheral haemodynamics was studied in healthy volunteers by strain gauge plethysmography after administration of ibopamine (IB), diisobutyric ester of N-methyl-dopamine, an orally active dopaminergic agonist. Seven subjects received a single oral dose of ibopamine of 150 mg and 6 received a daily dose of 150 mg (50 mg t.i.d.) for 5 consecutive days. Arterial resting blood flow and venous capacity increased and peripheral resistance decreased significantly. Six further subjects were then studied; 3 h after an oral dose of ibopamine 150 mg, the parenteral administration of Sulpiride 50 mg, a specific vascular dopaminergic antagonist, was found significantly to counteract its peripheral activity. Heart rate and arterial blood pressure were never affected and tolerability was good.
Authors:
C Longhini; G F Musacci; L Ansani; T Toselli; M Artioli; L Bianco; P Ghirardi
Related Documents :
10541734 - Sub-chronic administration of the dopamine d(1) antagonist skf 83959 in bilaterally mpt...
11682254 - Gamma vinyl-gaba differentially modulates nmda antagonist-induced increases in mesocort...
9888624 - Preferential involvement of d3 versus d2 dopamine receptors in the effects of dopamine ...
22005404 - A pilot study of the body weight of pure-bred client-owned adult cats.
16399164 - Toxicity and biodegradability assessment of raw and ozonated procaine penicillin g form...
23912694 - Pharmacogenetically driven patient selection for a first-in-human phase i trial of batr...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  24     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1983  
Date Detail:
Created Date:  1983-09-09     Completed Date:  1983-09-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  585-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Deoxyepinephrine / analogs & derivatives*,  pharmacology
Diuretics / pharmacology*
Dopamine / analogs & derivatives*
Female
Hemodynamics / drug effects*
Humans
Male
Sulpiride / pharmacology
Chemical
Reg. No./Substance:
0/Diuretics; 15676-16-1/Sulpiride; 501-15-5/Deoxyepinephrine; 66195-31-1/ibopamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of indapamide on the baroreceptor reflex in essential hypertension.
Next Document:  Amiodarone and pulmonary fibrosis.