Document Detail

Effect of ibopamine on peripheral haemodynamics.
MedLine Citation:
PMID:  6873134     Owner:  NLM     Status:  MEDLINE    
Peripheral haemodynamics was studied in healthy volunteers by strain gauge plethysmography after administration of ibopamine (IB), diisobutyric ester of N-methyl-dopamine, an orally active dopaminergic agonist. Seven subjects received a single oral dose of ibopamine of 150 mg and 6 received a daily dose of 150 mg (50 mg t.i.d.) for 5 consecutive days. Arterial resting blood flow and venous capacity increased and peripheral resistance decreased significantly. Six further subjects were then studied; 3 h after an oral dose of ibopamine 150 mg, the parenteral administration of Sulpiride 50 mg, a specific vascular dopaminergic antagonist, was found significantly to counteract its peripheral activity. Heart rate and arterial blood pressure were never affected and tolerability was good.
C Longhini; G F Musacci; L Ansani; T Toselli; M Artioli; L Bianco; P Ghirardi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  24     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1983  
Date Detail:
Created Date:  1983-09-09     Completed Date:  1983-09-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  585-9     Citation Subset:  IM    
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MeSH Terms
Deoxyepinephrine / analogs & derivatives*,  pharmacology
Diuretics / pharmacology*
Dopamine / analogs & derivatives*
Hemodynamics / drug effects*
Sulpiride / pharmacology
Reg. No./Substance:
0/Diuretics; 15676-16-1/Sulpiride; 501-15-5/Deoxyepinephrine; 66195-31-1/ibopamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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