Document Detail


Effect of hypoxia on reflex responses of tracheal submucosal glands.
MedLine Citation:
PMID:  7544338     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of moderate sustained normocapnic hypoxia on tracheal submucosal gland reflex responses were studied. Experiments were performed in anesthetized, paralyzed, and mechanically ventilated dogs. The changes in the number of secreting glands and volume of secreted fluid in the subsequent period of time were recorded after 15-30 min of controlled ventilation with room air [arterial PO2 (PaO2) 86 +/- 3 Torr], hypoxic gas mixture (PaO2 49 +/- 4 Torr), or 100% O2 (PaO2 339 +/- 39 Torr), under isocapnic and isohydric conditions. The hillocks method was used to quantify the changes in submucosal gland secretion. The changes in secretion 30 s after stimulation of pulmonary C-fiber receptors by right atrial injection of capsaicin (10 micrograms/kg; n = 10) were markedly lower during moderate hypoxia than in normoxia or hyperoxia. Differences in the number of liquid droplets and the volume of secreted fluid were statistically significant (P < 0.05 and P < 0.001, respectively). Stimulation of airway rapidly adapting receptors by lung deflation increased airway secretion; the number of "hillocks" and the volume of secreted fluid were lower in hypoxic than in hyperoxic state. Differences between response curves for the number of glands activated and secreted volume were statistically significant (P < 0.05 and P < 0.001). The number of glands activated by substance P given locally by arterial infusion was not affected by the state of oxygenation, but the calculated volume of secreted fluid was lower during the hypoxic state than under hyperoxic condition (P = 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
R Hejal; K P Strohl; B Erokwu; N S Cherniack; M A Haxhiu
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  78     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-09-27     Completed Date:  1995-09-27     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1651-6     Citation Subset:  IM; S    
Affiliation:
Department of Medicine, University Hospitals of Cleveland, Ohio 44106, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anoxia / physiopathology*
Dogs
Exocrine Glands / drug effects,  innervation,  physiopathology
Female
Male
Mucous Membrane / drug effects,  physiopathology
Nerve Endings / drug effects,  physiology
Nerve Fibers / physiology
Neurons, Afferent / drug effects,  physiology
Oxygen Consumption / drug effects
Pressoreceptors / drug effects,  physiology
Reflex / physiology*
Substance P / pharmacology
Trachea / drug effects,  innervation,  physiopathology*
Grant Support
ID/Acronym/Agency:
HL-25830/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
33507-63-0/Substance P

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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