| Effect of hypoxia on parathyroid hormone in lactating and neonatal rats: interaction with halothane. | |
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MedLine Citation:
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PMID: 12108514 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Low oxygen in the blood (hypoxemia) may occur in the neonate or women in the postpartum period. Administration of inhalation anesthetic may be required in this period. The purpose of this study was to evaluate the effect of 7 d of hypoxia on the neonatal rat pup and lactating dam without or with acute halothane anesthesia on serum calcium and calciotropic hormones. Ionized calcium was not altered by hypoxia or halothane administration. Hypoxia from birth had no effect on serum parathyroid hormone (PTH) in 7-d-old rat pups (48+/-4 pg/mL). Halothane increased PTH in rat pups (74+/-8 pg/mL). The effect of halothane was not augmented in hypoxic pups. Hypoxia for 7 d had no effect on serum PTH in lactating dams (23+/-3 pg/mL). Halothane resulted in an increase in PTH (106+/-17 pg/mL). When halothane was administered to hypoxic lactating dams, a striking increase in serum PTH was observed (401+/-50 pg/mL). We hypothesize that halothane and hypoxia alter parathyroid gland function by a direct effect on cellular calcium dynamics. This interaction may have clinical significance in hypoxic patients requiring general anesthesia. |
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Authors:
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Hershel Raff |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Endocrine Volume: 17 ISSN: 1355-008X ISO Abbreviation: Endocrine Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-07-10 Completed Date: 2002-12-24 Revised Date: 2010-06-24 |
Medline Journal Info:
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Nlm Unique ID: 9434444 Medline TA: Endocrine Country: United States |
Other Details:
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Languages: eng Pagination: 157-60 Citation Subset: IM |
Affiliation:
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Endocrine Research Laboratory, St Luke's Medical Center, Medical College of Wisconsin, Milwaukee, USA. hraff@mcw.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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25-Hydroxyvitamin D 2
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blood Anesthetics, Inhalation / pharmacology Animals Animals, Newborn / physiology* Anoxia / metabolism* Body Weight / drug effects Calcium / blood Female Halothane / pharmacology Lactation / physiology* Osteocalcin / blood Parathyroid Hormone / metabolism* Parturition / physiology Phosphates / blood Pregnancy Rats Rats, Sprague-Dawley |
| Grant Support | |
ID/Acronym/Agency:
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5 R01 DK54685/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 0/Parathyroid Hormone; 0/Phosphates; 104982-03-8/Osteocalcin; 151-67-7/Halothane; 21343-40-8/25-Hydroxyvitamin D 2; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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