Document Detail

Effect of hypoxia on noise-induced auditory impairment.
MedLine Citation:
PMID:  12361881     Owner:  NLM     Status:  MEDLINE    
Chemical asphyxiants have been shown to potentiate noise-induced hearing loss (NIHL) in our previous reports. However, it is still unclear whether hypoxia interacts with noise to potentiate NIHL. This is an important issue, since many people at risk of exposure to noise may also suffer from hypoxia. In the present study, rats were exposed to 14.1-kHz octave-band noise at 105, 110, and 115 dB SPL and hypoxic air (10% O(2) and 18% O(2)) for 4 h. Cochlear compound action potential threshold loss and hair cell loss were determined 4 weeks after the exposure. Though the hypoxia did not cause hearing loss and hair cell loss, the combined exposure to noise and hypoxic air caused more hearing loss and hair cell loss than the noise alone. The NIHL potentiation by hypoxia appeared to increase linearly with the hypoxia level. 10% O(2) exposure significantly potentiated NIHL and 18% O(2) exposure also showed an evident NIHL potentiation. This suggests that people suffering from hypoxia may have increased risk to noise trauma.
Guang-Di Chen
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hearing research     Volume:  172     ISSN:  0378-5955     ISO Abbreviation:  Hear. Res.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-03     Completed Date:  2003-03-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  186-95     Citation Subset:  IM    
University of Oklahoma Health Sciences Center, College of Pharmacy, P.O. Box 26901, Oklahoma City, OK 73190, USA.
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MeSH Terms
Action Potentials
Anoxia / complications*,  pathology,  physiopathology
Auditory Threshold
Evoked Potentials, Auditory
Hair Cells, Auditory / pathology
Hearing Loss, Noise-Induced / etiology*,  pathology,  physiopathology
Rats, Long-Evans
Risk Factors
Grant Support
1-R03-DC04753-01A1/DC/NIDCD NIH HHS

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