Document Detail

Effect of hypoxia on arterial and venous blood levels of oxygen, carbon dioxide, hydrogen ions and lactate during incremental forearm exercise.
MedLine Citation:
PMID:  2500338     Owner:  NLM     Status:  MEDLINE    
The purpose of the present study was to investigate whether, in humans, hypoxia results in an elevated lactate production from exercising skeletal muscle. Under conditions of both hypoxia [inspired oxygen fraction (F1O2): 11.10%] and normoxia (F1O2: 20.94%), incremental exercise of a forearm was performed. The exercise intensity was increased every minute by 1.6 kg.m.min-1 until exhaustion. During the incremental exercise the partial pressure of oxygen (PO2) and carbon dioxide (PCO2), oxygen saturation (SO2), pH and lactate concentration [HLa] of five subjects, were measured repeatedly in blood from the brachial artery and deep veins from muscles in the forearm of both the active and inactive sides. The hypoxia (arterial SO2 approximately 70%) resulted in (1) the difference in [HLa] in venous blood from active muscle (values during exercise-resting value) often being more than twice that for normoxia, (2) a significantly greater difference in venous-arterial (v-a) [HLa] for the exercising muscle compared to normoxia, and (3) a difference in v-a [HLa] for non-exercising muscle that was slightly negative during normoxia and more so with hypoxia. These studies suggest that lower O2 availability to the exercising muscle results in increased lactate production.
T Yoshida; M Udo; M Chida; M Ichioka; K Makiguchi
Related Documents :
18495828 - Phase i dynamics of cardiac output, systemic o2 delivery, and lung o2 uptake at exercis...
1474088 - Increased normoxic ventilation induced by repetitive hypoxia in conscious dogs.
8714538 - Brain tissue oxygen pressure, carbon dioxide pressure and ph during ischemia.
11812378 - Ventilation, eelv and diaphragmatic activity in rats during the early phase of normobar...
11831838 - Effect of verapamil in elderly patients with left ventricular diastolic dysfunction as ...
21943318 - Movement control exercise versus general exercise to reduce disability in patients with...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of applied physiology and occupational physiology     Volume:  58     ISSN:  0301-5548     ISO Abbreviation:  Eur J Appl Physiol Occup Physiol     Publication Date:  1989  
Date Detail:
Created Date:  1989-08-09     Completed Date:  1989-08-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0410266     Medline TA:  Eur J Appl Physiol Occup Physiol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  772-7     Citation Subset:  IM; S    
Exercise Physiology Laboratory, Faculty of Health and Sport Sciences, Osaka University, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anoxia / blood,  metabolism*
Carbon Dioxide / blood*
Hydrogen-Ion Concentration
Lactates / blood*
Muscles / metabolism*
Oxygen / blood*
Reg. No./Substance:
0/Lactates; 124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Genotoxic potency of three quinoline compounds evaluated in vivo in mouse marrow cells.
Next Document:  Functional analysis of the signal-sequence processing site of yeast acid phosphatase.