Document Detail

Effect of hypotension on the results of kidney storage and the use of dopamine under these conditions.
MedLine Citation:
PMID:  7025369     Owner:  NLM     Status:  MEDLINE    
The influence of the length and severity of hypotension on the results of kidney preservation was examined in dogs. Successful 24-hr hypothermic kidney storage was possible, if the donor animal was subjected to hypovolemic hypotension (mean blood pressure 60 mm Hg) for a duration 1 to 4 hr. If the blood pressure was lowered to 50 mm Hg, successful kidney preservation could not be obtained. It was concluded that the level of hypotension was of more importance than its duration. After 24 hr of cold ischemia, the function of kidneys from hypotensive donors could be improved significantly if dopamine was given to the recipient. The preservation injury itself could not be counteracted by dopamine because dopamine did not improve the function of kidneys which were removed from normotensive donors but were stored for 24 hr under hypothermia.
R Grundmann; B Kammerer; E Franke; H Pichlmaier
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transplantation     Volume:  32     ISSN:  0041-1337     ISO Abbreviation:  Transplantation     Publication Date:  1981 Sep 
Date Detail:
Created Date:  1981-11-18     Completed Date:  1981-11-18     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0132144     Medline TA:  Transplantation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  184-7     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Dopamine / pharmacology*
Hypotension / physiopathology*
Hypothermia, Induced / adverse effects
Kidney / blood supply,  drug effects
Kidney Transplantation*
Organ Preservation*
Tissue Preservation*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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