| Effect of hypophysectomy on schedule-induced wheelrunning. | |
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MedLine Citation:
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PMID: 2339163 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous research has shown that adrenalectomy suppresses schedule-induced wheelrunning, and that the suppressant effect of adrenalectomy can be totally reversed by the replacement of corticosterone. The present study confirms the role of the hormones of the pituitary adrenocortical axis in the control of schedule-induced wheelrunning by means of hypophysectomy. As anticipated, hypophysectomy also suppressed schedule-induced wheelrunning. The suppressant effect of hypophysectomy on schedule-induced wheelrunning was partially, but significantly restored by the implantation of corticosterone. Present findings, in conjunction with the previous work, show that schedule-induced wheelrunning is markedly dependent on the function of the pituitary-adrenal axis, and the nature of pituitary-adrenal involvement is mainly through circulating corticosterone levels. |
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Authors:
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W J Lin; G Singer; D Irby |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 35 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 1990 Mar |
Date Detail:
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Created Date: 1990-06-18 Completed Date: 1990-06-18 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 739-42 Citation Subset: IM |
Affiliation:
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Department of Psychology, La Trobe University, Bundoora, Victoria, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Corticosterone / blood, pharmacology* Drug Implants Hypophysectomy Male Motor Activity / drug effects, physiology* Pituitary-Adrenal System / metabolism, physiology* Rats |
| Chemical | |
Reg. No./Substance:
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0/Drug Implants; 50-22-6/Corticosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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