| Effect of hyperventilation on oxygenation of the brain cortex of neonates. | |
MedLine Citation:
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PMID: 1288095 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A new phosphorescence imaging method (Rumsey et al, Science (1988) 1649) has been used to continuously monitor the oxygen pressure in the blood of the cerebral cortex of newborn pigs. The animals' blood pressure was continuously measured and PaCO2, PaO2 and arterial blood pH were measured periodically. The oxygen pressure in the blood was quantitatively determined for regions of about 100 um square within the image (from a total field of about 3 mm diameter). It was observed that during hyperventilation, which lowered PaCO2 and increased pH of the blood, oxygen pressure decreased in proportion to the decrease in PaCO2. For example, hyperventilation which decreased PaCO2 from its normal value of 40 Torr to 10 Torr caused a rapid (within 5 minutes) decrease in oxygen pressure in the blood of capillaries and veins to approximately 1/4 of normal. |
Authors:
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D F Wilson; A Pastuszko; R Schneiderman; J E DiGiacomo; M Pawlowski; M Delivoria-Papadopoulos |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 316 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 1992 |
Date Detail:
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Created Date: 1993-03-18 Completed Date: 1993-03-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 341-6 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Biophysics, Medical School, University of Pennsylvania, Philadelphia 19104. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Cerebral Cortex / metabolism* Hyperventilation / metabolism* Hypocapnia / metabolism Kinetics Luminescent Measurements Molecular Probes Oxygen Consumption* Swine |
| Chemical | |
Reg. No./Substance:
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0/Molecular Probes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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