Document Detail


Effect of hyperventilation on oxygenation of the brain cortex of neonates.
MedLine Citation:
PMID:  1288095     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new phosphorescence imaging method (Rumsey et al, Science (1988) 1649) has been used to continuously monitor the oxygen pressure in the blood of the cerebral cortex of newborn pigs. The animals' blood pressure was continuously measured and PaCO2, PaO2 and arterial blood pH were measured periodically. The oxygen pressure in the blood was quantitatively determined for regions of about 100 um square within the image (from a total field of about 3 mm diameter). It was observed that during hyperventilation, which lowered PaCO2 and increased pH of the blood, oxygen pressure decreased in proportion to the decrease in PaCO2. For example, hyperventilation which decreased PaCO2 from its normal value of 40 Torr to 10 Torr caused a rapid (within 5 minutes) decrease in oxygen pressure in the blood of capillaries and veins to approximately 1/4 of normal.
Authors:
D F Wilson; A Pastuszko; R Schneiderman; J E DiGiacomo; M Pawlowski; M Delivoria-Papadopoulos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  316     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  1992  
Date Detail:
Created Date:  1993-03-18     Completed Date:  1993-03-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  341-6     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Biophysics, Medical School, University of Pennsylvania, Philadelphia 19104.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Cerebral Cortex / metabolism*
Hyperventilation / metabolism*
Hypocapnia / metabolism
Kinetics
Luminescent Measurements
Molecular Probes
Oxygen Consumption*
Swine
Chemical
Reg. No./Substance:
0/Molecular Probes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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