Document Detail


Effect of hyperventilation on brain tissue oxygen pressure, carbon dioxide pressure, pH value and intracranial pressure during intracranial hypertension in pigs.
MedLine Citation:
PMID:  11874678     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To study the effect of hyperventilat ion on brain tissue oxygen pressure (P(ti)O(2)), brain tissue carbon dio xide pressure (P(ti)O(2)), pH value and intracranial pressure (ICP) dur ing intracranial hypertension in pigs. METHODS: Autologous arterial blood (5.5 mlplus minus0.5 ml) was injected into the left frontal lobe by micropump to establish the model of intr acerebral hematoma in pigs. After blood injection, the animals were hyperventila ted for 15 minutes to decrease the pressure of carbon dioxide in arterial blood (P(a)CO(2)) to 27.35 mm Hgplus minus11.97 mm Hg (1 mm Hg=0.133 kPa). The mean arterial pressure (MAP), intracranial pressure (ICP), cerebral perfusion pressure (CPP), P(ti)O(2), (P(ti)CO(2)), pH value and [HCO(3)(-)] were continuously monitored and the blood gas was analyzed. RESULTS: After hyperventilation, the ICP significantly decr eased (P<0.01), the CPP significantly increased (P<0.05), while the P(ti)O(2) greatly decreased to t he ischemic level (8.20 mm Hgplus minus2.50 mm Hg) (P<0.01), the P(ti)CO(2) decreased (P<0.01) and the pH value increased (P<0.01). At the same time, bl ood gas analysis showed that the P(a)CO(2) greatly decreased and the pH valu e increased. CONCLUSIONS: Hyperventilation can decrease the ICP and the P(ti)O(2) significantly. Therefore, hyperventilation should be avoided earl y after brain injury. The P(ti)O(2) monitoring will be helpful for detec ting cerebral ischemia early.
Authors:
Yinghui Bao; Jiyao Jiang; Cheng Zhu; Yicheng Lu; Rujue Cai; Chiyuan Ma
Related Documents :
11989758 - Development of brain damage as measured by brain impedance recordings, and changes in h...
7760408 - Elevated intracranial pressure masks hemorrhagic hypotension in a canine model.
15995328 - Assessment of childhood intracranial pressure recordings using a new method of processi...
15305838 - Is there an upper limit of intracranial pressure in patients with severe head injury if...
1282968 - L-arginine as an antihypertensive agent.
14763898 - Can lymphatic drainage be measured non-invasively in human limbs, using plethysmography?
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Chinese journal of traumatology = Zhonghua chuang shang za zhi / Chinese Medical Association     Volume:  3     ISSN:  -     ISO Abbreviation:  Chin. J. Traumatol.     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2002-Mar-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886162     Medline TA:  Chin J Traumatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  210-213     Citation Subset:  -    
Affiliation:
Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Structural changes of neurons in hippocampus from infantile rats exposed to hyperbaric oxygen.
Next Document:  Analysis of urgent reconstruction of electrical injuries.