Document Detail


Effect of hyperoxia and vitamin C on coronary blood flow in patients with ischemic heart disease.
MedLine Citation:
PMID:  17303710     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pathological formation of reactive oxygen species within the coronary circulation has been hypothesized to mediate some clinical manifestations of ischemic heart disease (IHD) by interfering with physiological regulation of coronary tone. To determine the degree to which coronary tone responds to acute changes in ambient levels of oxidants and antioxidants in vivo in a clinical setting, we measured the effect of an acute oxidative stress (breathing 100% oxygen) on coronary capacitance artery diameter (quantitative angiography) and blood flow velocity through the coronary microcirculation (intracoronary Doppler ultrasonography) before and after treatment with the antioxidant vitamin C (3-g intravenous infusion) in 12 IHD patients undergoing a clinical coronary interventional procedure. Relative to room air breathing, 100% oxygen breathing promptly reduced coronary blood flow velocity by 20% and increased coronary resistance by 23%, without significantly changing the diameter of capacitance arteries. Vitamin C administration promptly restored coronary flow velocity and resistance to a slightly suprabasal level, and it prevented the reinduction of coronary constriction with rechallenge with 100% oxygen. This suggests that acute oxidative stress produces prompt and substantial changes in coronary resistance and blood flow in a clinical setting in patients with IHD, and it suggests that these changes are mediated by vitamin C-quenchable substances acting on the coronary microcirculation. This observation may have relevance for clinical practice.
Authors:
Patrick H McNulty; Bryan J Robertson; Mark A Tulli; Joshua Hess; Lisa A Harach; Sofia Scott; Lawrence I Sinoway
Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-02-15
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  102     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-07     Completed Date:  2007-07-13     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2040-5     Citation Subset:  IM    
Affiliation:
Div. of Cardiology, Penn State College of Medicine, Hershey, Pennsylvania, USA. patrick.mcnulty@Bassett.org
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MeSH Terms
Descriptor/Qualifier:
Aged
Antioxidants / administration & dosage,  pharmacology*,  therapeutic use
Ascorbic Acid / administration & dosage,  pharmacology*,  therapeutic use
Blood Flow Velocity / drug effects
Coronary Angiography
Coronary Circulation / drug effects*
Coronary Vessels / drug effects*,  metabolism,  physiopathology
Female
Humans
Hyperoxia / metabolism,  pathology,  physiopathology*
Infusions, Intravenous
Laser-Doppler Flowmetry
Male
Middle Aged
Myocardial Ischemia / drug therapy,  metabolism,  pathology,  physiopathology*
Oxidative Stress / drug effects*
Vascular Resistance / drug effects
Grant Support
ID/Acronym/Agency:
M01 RR10732/RR/NCRR NIH HHS; R01-HL-070222/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Antioxidants; 50-81-7/Ascorbic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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