Document Detail


Effect of hyperoxia at 1 and 2 ATA on hypoxia and hypercapnia in human skin during experimental inflammation.
MedLine Citation:
PMID:  8002526     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transcutaneous PO2 and PCO2 measurements and estimates of skin respiration were monitored at different levels of inspired PO2 in 20 healthy adults during the first 4 days of the tuberculin reaction, a convenient model of acute inflammation. Hyperoxia at 1 and 2 ATA significantly increased transcutaneous PO2 levels in undisturbed and in inflamed skin but did not fully correct the relative hypoxia at the site of inflammation. Hypercapnia was reduced with O2 breathing at 2 ATA. The apparent rate of O2 consumption at the reaction site was raised during hyperoxia, most prominently at 2 ATA. The most intense reactions showed a central relative slowing of laser-Doppler blood flow indicative of microcirculatory impairment. The extent of the relative hypoxia and hypercapnia was greatest in these strongest reactions. The density of lymphocytes and monocytes in biopsies of 48-h reactions was loosely related to the corresponding transcutaneous PO2 measurements. The present study provides evidence that diffusion barriers, in addition to increased local respiration, can contribute to the apparent hypoxia and hypercapnia of this inflammatory model.
Authors:
N C Abbot; J S Beck; F M Carnochan; J H Gibbs; D K Harrison; P B James; J G Lowe
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  77     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1995-01-20     Completed Date:  1995-01-20     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  767-73     Citation Subset:  IM; S    
Affiliation:
Pathology Department, University of Dundee, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anoxia / physiopathology*
Atmospheric Pressure*
Carbon Dioxide / blood
Dermatitis / physiopathology*
Female
Humans
Hypercapnia / physiopathology*
Hyperoxia / metabolism*
Male
Microcirculation
Oxygen / blood
Tuberculin Test
Chemical
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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