Document Detail


Effect of hyperosmolality on control of blood flow and sweating.
MedLine Citation:
PMID:  6511544     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To study the effect of hyperosmolality on thermoregulatory responses, five men [average maximal O2 consumption (VO2 max) = 48 ml X kg-1 X min-1] cycled at 65-75% VO2max for up to 30 min in a 30 degrees C, 40% relative humidity environment under three conditions. First, control tests (C) were performed where preexercise plasma volume (PV) and osmolality (Osm) averaged 3,800 ml and 282 mosmol X kg-1, respectively. Second, exercise tests (D) were performed following dehydration induced by fluid restriction and mild exercise (30% VO2max) in hot (40 degrees C) ambient conditions. Each subject then rested in cool surroundings 1 h before performing the exercise test. Preexercise PV and Osm averaged 3,606 ml and 293 mosmol X kg-1, respectively. Third, exercise tests (I) were performed following dehydration, but during the 1-h rest interval, 3% saline was infused so that PV was restored to 3,826 ml and Osm averaged 294 mosmol X kg-1 prior to exercise. During D, esophageal temperatures (Tes) were significantly higher than C, an avg 0.56 degrees C after 20 min exercise due to a 0.22 degrees C increase in Tes threshold for vasodilation, a 39% reduction in slope of the forearm blood flow (BF)-Tes relationship, a 32% average reduction in maximal exercise BF, and a 0.22 degrees C increase in Tes sweating threshold. During I, responses were similar to D, except the BF-Tes slope and the maximum BF were not significantly different from C. Thus hyperosmolality modifies thermoregulation by elevating thresholds for both vasodilation and sweating even without decreases in PV.
Authors:
S M Fortney; C B Wenger; J R Bove; E R Nadel
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology: respiratory, environmental and exercise physiology     Volume:  57     ISSN:  0161-7567     ISO Abbreviation:  J Appl Physiol Respir Environ Exerc Physiol     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1985-02-19     Completed Date:  1985-02-19     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  7801242     Medline TA:  J Appl Physiol Respir Environ Exerc Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1688-95     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Circulation*
Blood Physiological Phenomena*
Blood Volume
Body Fluids / metabolism
Body Temperature
Body Weight / drug effects
Dehydration / metabolism,  physiopathology
Humans
Male
Osmolar Concentration
Physical Exertion
Saline Solution, Hypertonic / pharmacology
Sweating*
Grant Support
ID/Acronym/Agency:
ES-00354/ES/NIEHS NIH HHS; HL-17732/HL/NHLBI NIH HHS; HL-20634/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Saline Solution, Hypertonic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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