| Effect of hyperhomocysteinemia induced by methionine administration on flow-mediated dilatation of the brachial artery in healthy subjects. | |
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MedLine Citation:
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PMID: 15670563 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Homocysteine may contribute to systolic hypertension and cardiac events by decreasing conduit artery compliance and inducing endothelial dysfunction. The effects of the experimental induction of hyperhomocysteinemia on systemic arterial compliance and pulsewave velocity are unclear, with contradictory results from previous studies. The investigators tested whether oral methionine impairs brachial artery compliance in addition to endothelial function. |
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Authors:
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Moutasim H Al-Shaer; Geetha Raghuveer; Roger Browning; Christine A Sinkey; Catherine Chenard; Phyllis Stumbo; William G Haynes |
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Publication Detail:
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Type: Clinical Trial; Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of cardiology Volume: 95 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-01-26 Completed Date: 2005-03-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 428-30 Citation Subset: AIM; IM |
Affiliation:
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Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Brachial Artery / drug effects, ultrasonography Cross-Over Studies Double-Blind Method Female Humans Hyperhomocysteinemia / chemically induced* Linear Models Male Methionine / administration & dosage, pharmacology* Ultrasonography, Doppler |
| Grant Support | |
ID/Acronym/Agency:
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HL58972/HL/NHLBI NIH HHS; RR000059/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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63-68-3/Methionine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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