Document Detail

Effect of hypercapnia on net filtration of fluid in the lungs of awake newborn lambs.
MedLine Citation:
PMID:  7263449     Owner:  NLM     Status:  MEDLINE    
To study the effect of hypercapnia on net transvascular filtration of fluid in newborn lungs, we measured pulmonary arterial and left pressures and collected lung lymph from 11 awake 2-wk-old lambs as they spontaneously breathed a gas mixture rich in carbon dioxide. After a 2-h control period in air, the lambs breathed 8-11% carbon dioxide mixed with air and nitrogen for 2-6 h. Average pulmonary arterial pressure and blood flow to the lungs increased during hypercapnia, but pulmonary vascular resistance did not change. In all cases, hypercapnia led to an acute transient increase in lymph flow. During sustained hypercapnia, however, flow of lymph was not significantly different from flow measured during the control period. The concentration of protein in lymph decreased at the onset of hypercapnia and remained low during sustained hypercapnia. These results suggest that acute hypercapnia increases net filtration by increasing the transvascular gradient of hydraulic pressure, whereas, in a "steady-state," neither hypercapnia nor the tachypnea that accompanies it alters net transvascular filtration of fluid in the lungs of unanesthetized newborn animals.
C M Haberkern; R D Bland
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology: respiratory, environmental and exercise physiology     Volume:  51     ISSN:  0161-7567     ISO Abbreviation:  J Appl Physiol Respir Environ Exerc Physiol     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1981-10-25     Completed Date:  1981-10-25     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  7801242     Medline TA:  J Appl Physiol Respir Environ Exerc Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  423-7     Citation Subset:  IM; S    
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MeSH Terms
Animals, Newborn
Blood Pressure
Capillary Permeability*
Hypercapnia / physiopathology*
Lung / blood supply,  physiopathology*
Lymph / physiology
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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