| Effect of hyperbaric oxygen therapy on survival after global cerebral ischemia in rats. | |
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MedLine Citation:
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PMID: 9537659 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Hyperbaric oxygenation (HBO) has been considered for many years for the treatment of severe brain ischemia. However, its efficacy has not been proven. The aim of this study was to shed light on this question. METHODS: Acute global cerebral ischemia was induced in 18 rats using the four-vessel occlusion model. Regional cerebral blood flow (CBF) was determined by laser-Doppler flowmetry using a flexible 1 mm fiberoptic probe. Two stainless steel screws were used to measure the spontaneous electrical activity from the contralateral hemisphere. After ischemia monitored by laser-Doppler flowmetry and ECoG, the animals were divided into two groups: (1) control animals that breathed air at atmospheric pressure and (2) rats exposed to HBO at three atmospheres absolute pressure (ATA) for 1 hour. Survival time and rate were recorded for both groups of animals for 14 days. RESULTS: The survival rate in the study group was significantly higher (45%) than in the control group (0%). In the animals that did not survive the 14-day period, those exposed to HBO survived longer than the control animals (59.8+/-9.1 hour versus 17.9+/-2.7 hours, p < 0.05). CONCLUSION: This investigation demonstrates that HBO administered after global cerebral ischemia can increase survival in a rat stroke model. |
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Authors:
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M Krakovsky; G Rogatsky; N Zarchin; A Mayevsky |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Surgical neurology Volume: 49 ISSN: 0090-3019 ISO Abbreviation: Surg Neurol Publication Date: 1998 Apr |
Date Detail:
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Created Date: 1998-04-14 Completed Date: 1998-04-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0367070 Medline TA: Surg Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 412-6 Citation Subset: IM |
Affiliation:
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Department of Life Sciences, Bar-Ilan University, Ramat Gan, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Ischemia / physiopathology*, therapy* Cerebrovascular Circulation* Hyperbaric Oxygenation* Laser-Doppler Flowmetry Male Rats Rats, Wistar Survival Analysis |
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