Document Detail

Effect of hyperbaric oxygen on the immunoreactivity to substance P in the nasal mucosa of cluster headache patients.
MedLine Citation:
PMID:  8675426     Owner:  NLM     Status:  MEDLINE    
Exposure to hyperbaric oxygen has been shown to be effective in cluster headache, but the mechanism of the action is still not clear. Primary nociceptive neurons, containing neuropeptides such as substance P and particularly those innervating the nasal mucosa, could be involved in the pathogenesis of cluster headache. The present study evaluated the effect of an exposure to hyperbaric oxygen on the content of substance P in the nasal mucosa of patients affected by cluster headache. The results were compared with those observed in another group of cluster headache patients who underwent a placebo procedure. The samples of nasal mucosa were analyzed by immunocytochemical methods. A qualitative analysis of the slides was carried out by an operator under "blinded conditions". A marked decrease in the content of immunoreactivity for substance P was found in the patients exposed to hyperbaric oxygen. The decrease was statistically significant when compared with the findings of the placebo procedure. The results of the present study indicate that an influence on the content of peripheral neuropeptides could be involved in the mechanism of action of the beneficial effect of hyperbaric oxygen in cluster headache.
F Di Sabato; M Giacovazzo; G Cristalli; M Rocco; B M Fusco
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Headache     Volume:  36     ISSN:  0017-8748     ISO Abbreviation:  Headache     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-08-12     Completed Date:  1996-08-12     Revised Date:  2009-02-02    
Medline Journal Info:
Nlm Unique ID:  2985091R     Medline TA:  Headache     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  221-3     Citation Subset:  IM    
Institute of Internal Medicine VI, Headache Center, University La Sapienza Rome, Italy.
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MeSH Terms
Antigen-Antibody Reactions*
Cluster Headache / immunology*,  therapy*
Hyperbaric Oxygenation*
Middle Aged
Nasal Mucosa / immunology*
Substance P / immunology*
Reg. No./Substance:
33507-63-0/Substance P

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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