Document Detail

Effect of hydroxyurea on sperm count, motility and morphology in adult men with sickle cell or myeloproliferative disease.
MedLine Citation:
PMID:  17316339     Owner:  NLM     Status:  MEDLINE    
Hydroxyurea (HU) is not infrequently used in patients with sickle cell disease and myeloproliferative disorders. Despite murine data showing adverse effects on sperm counts, motility and morphology, there is little information on the effect of HU on human spermatogenesis. A retrospective review of four adult men who had semen analysis during HU therapy and in three cases after its cessation suggests that HU generally reduces sperm counts and motility and results in abnormal morphology. Cessation of HU in one case with azoospermia resulted in recovery of spermatogenesis; in two of the three cases, however, sperm morphology and mobility remained impaired. Recommendations for fertility management in adult men receiving long-term HU therapy are proposed.
A Grigg
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Internal medicine journal     Volume:  37     ISSN:  1445-5994     ISO Abbreviation:  Intern Med J     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-23     Completed Date:  2007-03-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101092952     Medline TA:  Intern Med J     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  190-2     Citation Subset:  IM    
Department of Clinical Haematology, The Royal Melbourne Hospital, Melbourne, Victoria, Australia.
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MeSH Terms
Anemia, Sickle Cell / drug therapy*,  pathology,  physiopathology
Antisickling Agents / adverse effects*,  therapeutic use
Azoospermia / chemically induced
Hydroxyurea / adverse effects*,  therapeutic use
Myeloproliferative Disorders / drug therapy*,  pathology,  physiopathology
Nucleic Acid Synthesis Inhibitors / adverse effects*,  therapeutic use
Retrospective Studies
Sperm Count
Sperm Motility / drug effects
Spermatozoa / drug effects*,  ultrastructure
Reg. No./Substance:
0/Antisickling Agents; 0/Nucleic Acid Synthesis Inhibitors; 127-07-1/Hydroxyurea

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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