| Effect of hydroxyurea on sperm count, motility and morphology in adult men with sickle cell or myeloproliferative disease. | |
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MedLine Citation:
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PMID: 17316339 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hydroxyurea (HU) is not infrequently used in patients with sickle cell disease and myeloproliferative disorders. Despite murine data showing adverse effects on sperm counts, motility and morphology, there is little information on the effect of HU on human spermatogenesis. A retrospective review of four adult men who had semen analysis during HU therapy and in three cases after its cessation suggests that HU generally reduces sperm counts and motility and results in abnormal morphology. Cessation of HU in one case with azoospermia resulted in recovery of spermatogenesis; in two of the three cases, however, sperm morphology and mobility remained impaired. Recommendations for fertility management in adult men receiving long-term HU therapy are proposed. |
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Authors:
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A Grigg |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Internal medicine journal Volume: 37 ISSN: 1445-5994 ISO Abbreviation: Intern Med J Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-02-23 Completed Date: 2007-03-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101092952 Medline TA: Intern Med J Country: Australia |
Other Details:
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Languages: eng Pagination: 190-2 Citation Subset: IM |
Affiliation:
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Department of Clinical Haematology, The Royal Melbourne Hospital, Melbourne, Victoria, Australia. andrew.grigg@mh.org.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anemia, Sickle Cell / drug therapy*, pathology, physiopathology Antisickling Agents / adverse effects*, therapeutic use Azoospermia / chemically induced Humans Hydroxyurea / adverse effects*, therapeutic use Male Myeloproliferative Disorders / drug therapy*, pathology, physiopathology Nucleic Acid Synthesis Inhibitors / adverse effects*, therapeutic use Oligospermia Retrospective Studies Sperm Count Sperm Motility / drug effects Spermatozoa / drug effects*, ultrastructure |
| Chemical | |
Reg. No./Substance:
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0/Antisickling Agents; 0/Nucleic Acid Synthesis Inhibitors; 127-07-1/Hydroxyurea |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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