Document Detail

Effect of hydroxyurea on foetal haemoglobin in myeloproliferative & myelodysplastic syndromes.
MedLine Citation:
PMID:  1695200     Owner:  NLM     Status:  MEDLINE    
The effect of hydroxyurea on foetal haemoglobin (HbF) levels was evaluated in 36 patients of myeloproliferative and myelodysplastic disorders. In 17 (47.2%) patients, HbF levels increased from 1.40 +/- 1.17 to 3.03 +/- 1.97 per cent after 4 wk therapy with hydroxyurea. In the responders this increase was highly significant (P less than 0.001). The rise in the HbF levels after hydroxyurea therapy was significant in patients with chronic myeloid leukaemia but not in the other groups.
S H Advani; P Venugopal; B S Charak; A Das Gupta; A T Mazumdar; R Gopal; C N Nair; T K Saikia; K S Nadkarni; P A Kurkure
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Indian journal of medical research     Volume:  92     ISSN:  0971-5916     ISO Abbreviation:  Indian J. Med. Res.     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-08-23     Completed Date:  1990-08-23     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  0374701     Medline TA:  Indian J Med Res     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  83-5     Citation Subset:  IM    
Department of Medical Oncology, Tata Memorial Hospital, Bombay.
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MeSH Terms
Fetal Hemoglobin / analysis*
Hydroxyurea / pharmacology*
Middle Aged
Myelodysplastic Syndromes / blood*
Myeloproliferative Disorders / blood*
Reg. No./Substance:
127-07-1/Hydroxyurea; 9034-63-3/Fetal Hemoglobin

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