Document Detail


Effect of -hydroxybutyrate on the release of monoamines from the rat striatum.
MedLine Citation:
PMID:  5041458     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A simple in vitro system was developed to study the effect of gamma-hydroxybutyrate on nerve cell depolarization-induced release of labelled DA and 5-hydroxytryptamine. The release of (3)H-dopamine formed in rat striatal slices incubated with (3)3H-tyrosine was followed. A three minute exposure to K+ (53.0 mM) caused a thirty-fold increase in the release of newly synthesized (3)H-dopamine. This K + -induced release was antagonized when gamma-hydroxybutyrate (1 mM) was present in the medium. Potassium (53.0 mM) increased (eighteen-fold) the release of (3)H-dopamine from striatal slices initially loaded by preincubation with (3)H-dopamine. The K + -induced release of this pool of DA was, however, not antagonized by gamma-hydroxybutyrate.Potassium (53.0 mM) also increased the release from striatal slices of (3)H-5-hydroxytryptamine (5-HT) newly synthesized from (3)H-tryptophan. This K + -induced release of 5-HT was also not inhibited by gamma-hydroxybutyrate. The ability of gamma-hydroxybutyrate to antagonize only the K + -induced release of newly formed DA may explain why this agent causes a rapid and selective increase in brain dopamine.
Authors:
G Bustos; R H Roth
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of pharmacology     Volume:  44     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1972 Apr 
Date Detail:
Created Date:  1972-09-12     Completed Date:  1972-09-12     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  817-20     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Corpus Striatum / drug effects,  metabolism
Dopamine / metabolism*
Hydroxybutyrates / pharmacology*
Male
Potassium / pharmacology
Rats
Serotonin / metabolism*
Time Factors
Tritium
Tyrosine / metabolism
Chemical
Reg. No./Substance:
0/Hydroxybutyrates; 10028-17-8/Tritium; 50-67-9/Serotonin; 55520-40-6/Tyrosine; 7440-09-7/Potassium
Comments/Corrections

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