Document Detail


Effect of hydrocortisone on the metabolism of phosphatidylcholine in maternal and fetal rabbit lungs and livers.
MedLine Citation:
PMID:  503666     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Administration of hydrocortisone to pregnant rabbits caused a decrease in weights of fetal body and lung and an increase in the incorporation of choline into fetal lung PC. The authors found no induction of the enzymes related to the incorporation of choline into PC in fetal lung. Also, there was no stimulation of any enzymatic activity of CDP-choline pathway or PC-lysoPC cycle pathway in maternal lung and liver or fetal liver. In addition to the acceleration of choline incorporation into fetal lung PC by the cortisol, hydrocortisone also significantly stimulated the secretion of lung PC affected by glucocorticoids may also be related to apparent fetal lung maturation.
Authors:
F H Tsao; G R Gutcher; R D Zachman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatric research     Volume:  13     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1979 Sep 
Date Detail:
Created Date:  1980-01-19     Completed Date:  1980-01-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  997-1001     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cytidine Diphosphate Choline / metabolism
Female
Hydrocortisone / pharmacology*
Liver / drug effects*,  embryology,  enzymology,  metabolism
Lung / drug effects*,  embryology,  metabolism
Maternal-Fetal Exchange*
Phosphatidylcholines / metabolism*
Pregnancy
Rabbits
Chemical
Reg. No./Substance:
0/Phosphatidylcholines; 50-23-7/Hydrocortisone; 987-78-0/Cytidine Diphosphate Choline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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