| Effect of hydrocortisone on the metabolism of phosphatidylcholine in maternal and fetal rabbit lungs and livers. | |
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MedLine Citation:
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PMID: 503666 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Administration of hydrocortisone to pregnant rabbits caused a decrease in weights of fetal body and lung and an increase in the incorporation of choline into fetal lung PC. The authors found no induction of the enzymes related to the incorporation of choline into PC in fetal lung. Also, there was no stimulation of any enzymatic activity of CDP-choline pathway or PC-lysoPC cycle pathway in maternal lung and liver or fetal liver. In addition to the acceleration of choline incorporation into fetal lung PC by the cortisol, hydrocortisone also significantly stimulated the secretion of lung PC affected by glucocorticoids may also be related to apparent fetal lung maturation. |
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Authors:
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F H Tsao; G R Gutcher; R D Zachman |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Pediatric research Volume: 13 ISSN: 0031-3998 ISO Abbreviation: Pediatr. Res. Publication Date: 1979 Sep |
Date Detail:
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Created Date: 1980-01-19 Completed Date: 1980-01-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 997-1001 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cytidine Diphosphate Choline / metabolism Female Hydrocortisone / pharmacology* Liver / drug effects*, embryology, enzymology, metabolism Lung / drug effects*, embryology, metabolism Maternal-Fetal Exchange* Phosphatidylcholines / metabolism* Pregnancy Rabbits |
| Chemical | |
Reg. No./Substance:
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0/Phosphatidylcholines; 50-23-7/Hydrocortisone; 987-78-0/Cytidine Diphosphate Choline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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