| Effect of hydration on lung interstitial conductivity response to electrically charged solutions. | |
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MedLine Citation:
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PMID: 9342803 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In interstitial segments of rabbit lung, we compared the flow of a solution containing cationic protamine sulfate (0.08 mg/ml) or cationic dextran (0.1%) to that of Ringer or neutral dextran solution. Also compared, were the flow of solutions containing anionic dextran (0.1 or 1.5%) to those containing neutral dextran and the flow of hyaluronidase solution (0.02%) to that of Ringer solution, at mean interstitial pressures (Pm) between -5 and 15 cmH2O. Driving pressure was set at 5 cmH2O. Cationic protamine or cationic dextran-to-Ringer flow ratio increased with Pm (presumably as hydration increased) but in nonedematous interstitium (-5 cmH2O Pm), flow ratio was 1, indicating a viscosity-dependent flow. In contrast, the flow of anionic dextran solution decreased relative to that of neutral dextran; this decrease was constant with hydration, but was greater at the higher concentration of dextran. Interstitial conductivity to the flow of hyaluronidase increased with hydration. However, this behavior was absent after the flow of 1.5% anionic dextran, indicating an inhibitory effect of the higher concentration of anionic dextran on the hyaluronidase response. A negative charge in microvascular filtrate may control fluid clearance in normal interstitium, while a positive charge would enhance clearance only in edema formation. |
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Authors:
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X L Qiu; L V Brown; S J Lai-Fook |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Respiration physiology Volume: 109 ISSN: 0034-5687 ISO Abbreviation: Respir Physiol Publication Date: 1997 Sep |
Date Detail:
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Created Date: 1997-12-05 Completed Date: 1997-12-05 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0047142 Medline TA: Respir Physiol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 261-72 Citation Subset: IM |
Affiliation:
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Wenner-Gren Research Laboratory, University of Kentucky, Lexington 40506-0070, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anions / pharmacology Capillary Permeability Cations / pharmacology Dextrans / pharmacology Electric Conductivity Extravascular Lung Water / physiology* Hyaluronoglucosaminidase Hydrostatic Pressure Lung / blood supply, physiology* Microcirculation Protamines / pharmacology Rabbits |
| Grant Support | |
ID/Acronym/Agency:
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HL 40362/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anions; 0/Cations; 0/Protamines; 9004-54-0/Dextrans; EC 3.2.1.35/Hyaluronoglucosaminidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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