| Effect of humidity on hyperoxic toxicity. | |
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MedLine Citation:
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PMID: 8307849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Time to onset of hyperbaric oxygen-induced convulsions was measured in mice and rats exposed to hyperbaric oxygen (515-585 kPa) under conditions of low humidity (dry gas, < 10% relative humidity) or in a humidified environment (60% relative humidity). At all pressures tested, the duration of convulsive activity was markedly increased (P < 0.001), because of the earlier onset of severe generalized convulsions, in the groups of rodents exposed to the higher humidity. Pulmonary oxygen poisoning was determined by increases in lung wet and dry weights. Such pulmonary damage was also significantly (P < 0.001) increased in the humidified groups. Hyperoxic toxicity was also measured in rats and mice exposed to approximately 100% oxygen (normobaric hyperoxia) under conditions of 30 or 62% relative humidity. In contrast to the results obtained with hyperbaric oxygen exposure, there was slightly less toxicity in the rodents maintained at 62% compared with 30% humidity in normobaric hyperoxia. |
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Authors:
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Y Lin; D Jamieson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 75 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1993 Nov |
Date Detail:
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Created Date: 1994-03-17 Completed Date: 1994-03-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1980-3 Citation Subset: IM; S |
Affiliation:
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School of Physiology and Pharmacology, University of New South Wales, Kensington, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature / physiology Humidity / adverse effects* Hyperbaric Oxygenation / adverse effects Lung Diseases / chemically induced, pathology* Male Mice Mice, Inbred BALB C Organ Size / physiology Oxygen / toxicity* Rats Rats, Wistar Seizures / etiology, physiopathology |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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