Document Detail

Effect of humidity on hyperoxic toxicity.
MedLine Citation:
PMID:  8307849     Owner:  NLM     Status:  MEDLINE    
Time to onset of hyperbaric oxygen-induced convulsions was measured in mice and rats exposed to hyperbaric oxygen (515-585 kPa) under conditions of low humidity (dry gas, < 10% relative humidity) or in a humidified environment (60% relative humidity). At all pressures tested, the duration of convulsive activity was markedly increased (P < 0.001), because of the earlier onset of severe generalized convulsions, in the groups of rodents exposed to the higher humidity. Pulmonary oxygen poisoning was determined by increases in lung wet and dry weights. Such pulmonary damage was also significantly (P < 0.001) increased in the humidified groups. Hyperoxic toxicity was also measured in rats and mice exposed to approximately 100% oxygen (normobaric hyperoxia) under conditions of 30 or 62% relative humidity. In contrast to the results obtained with hyperbaric oxygen exposure, there was slightly less toxicity in the rodents maintained at 62% compared with 30% humidity in normobaric hyperoxia.
Y Lin; D Jamieson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  75     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-03-17     Completed Date:  1994-03-17     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1980-3     Citation Subset:  IM; S    
School of Physiology and Pharmacology, University of New South Wales, Kensington, Australia.
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MeSH Terms
Body Temperature / physiology
Humidity / adverse effects*
Hyperbaric Oxygenation / adverse effects
Lung Diseases / chemically induced,  pathology*
Mice, Inbred BALB C
Organ Size / physiology
Oxygen / toxicity*
Rats, Wistar
Seizures / etiology,  physiopathology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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