Document Detail

Effect of human placental lactogen upon the human corpus luteum of late pregnancy.
MedLine Citation:
PMID:  35449     Owner:  NLM     Status:  MEDLINE    
To acertain whether human placental lactogen (HPL) functions as a luteotropin during pregnancy in humans, studies were performed to determine if receptors for HPL are present in cells of the human corpus luteum of late pregnancy. Preparations of 125I-HPL which demonstrated specific binding to late pregnant rabbit mammary gland cell homogenates showed specific binding of less than 2.5% to homogenates of human corpora lutea of late pregnancy. These studies indicate that HPL is not luteotropic at this stage of pregnancy in humans. The action of HPL upon the corpus luteum appears to vary considerably according to species.
L T Goldsmith; J A Hochman; G Weiss
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Gynecologic investigation     Volume:  9     ISSN:  0017-5986     ISO Abbreviation:  Gynecol Invest     Publication Date:  1978  
Date Detail:
Created Date:  1979-07-25     Completed Date:  1979-07-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0245073     Medline TA:  Gynecol Invest     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  210-8     Citation Subset:  IM    
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MeSH Terms
Chorionic Gonadotropin / metabolism
Corpus Luteum / metabolism*
Hydrogen-Ion Concentration
Mammary Glands, Animal / metabolism
Placental Lactogen / metabolism*
Receptors, Cell Surface / metabolism*
Species Specificity
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Receptors, Cell Surface; 9035-54-5/Placental Lactogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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