Document Detail

Effect of human milk fortification in appropriate for gestation and small for gestation preterm babies: a randomized controlled trial.
MedLine Citation:
PMID:  17468524     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the effects of human milk fortification on short term growth and biochemical parameters in preterm very low birth weight (VLBW) appropriate for gestation (AGA) and small for gestation (SGA) babies. DESIGN: Prospective, randomized controlled trial. SETTING: Level III neonatal unit. SUBJECTS: Preterm infants weighing < or = 1500 grams and < or = 34 weeks of gestation born between March 2001 to June 2002. METHODS: Babies (n =166) were randomized in two groups either to get fortified human milk or exclusive human milk along with mineral and vitamin supplementation when feed volume reached 150 mL/Kg/day. Fortification was done with a powdered fortifier added in expressed breast milk and continued till the baby reached 2 Kg or full breast feeds. Primary outcome measures were Short-term growth (daily weight, length and head circumference (HC) weekly) till discharge or 2 Kg. RESULTS: Fortification (n = 85, birth weight 1202 g, gestation 30.8 wk) resulted in better growth in preterm VLBW babies as compared to control group (n=81, birth weight 1259 g, gestation 31.3 wk). Weight gain (15.1 and 12.9 g/kg/d, P <0.001), length (1.04 and 0.86 cm/week, P = 0.017) and HC (0.83 and 0.75 cm/week, P<0.001) increased significantly in fortified group. SGA babies showed significant improvements in weight (16 g/Kg/d and 12.9 g/kg/d, P = 0.002) and length (1.09 cm/week and 0.92 cm/week, P = 0.042) in fortified group (n = 38) as compared to control group (n = 29). In AGA subgroup, there was significant increase (P = 0.006) in length (1 cm vs 0.82 cm) in fortified group but no difference in weight (P = 0.12) or HC (P=0.054) in fortified (n=47) vs control (n=52) group. Biochemical parameters were comparable, however feed intolerance was more in control group. CONCLUSION: Preterm VLBW babies showed better growth with human milk fortification. The effect is significant in SGA (weight and length)rather than AGA (only length) babies.
Kanya Mukhopadhyay; Anil Narnag; Rama Mahajan
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Indian pediatrics     Volume:  44     ISSN:  0019-6061     ISO Abbreviation:  Indian Pediatr     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-30     Completed Date:  2007-06-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  2985062R     Medline TA:  Indian Pediatr     Country:  India    
Other Details:
Languages:  eng     Pagination:  286-90     Citation Subset:  IM    
Division of Neonatology, Department of Pediatrics, PGIMER, Chandigarh 160 012, India.
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MeSH Terms
Food, Fortified*
Infant Formula*
Infant Nutritional Physiological Phenomena*
Infant, Newborn
Infant, Premature / physiology*
Infant, Small for Gestational Age / physiology*
Infant, Very Low Birth Weight / physiology*
Milk, Human*
Weight Gain*
Comment In:
Indian Pediatr. 2008 Apr;45(4):333; author reply 333-4   [PMID:  18451461 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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