Document Detail


Effect of human leukocyte interferon on hepatitis B virus infection in patients with chronic active hepatitis.
MedLine Citation:
PMID:  950957     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Four patients with chronic hepatitis B infection and chronic active hepatitis were treated with human leukocyte interferon. Three of them had consistently elevated levels of circulating Dane-particle markers, including Dane-particle-associated DNA polymerase activity, hepatitis B core antigen and Dane-particle-associated DNA. Parenteral interferon administration at a dosage between 6.0 X 10(3) and 17 X 10(4) U per kilogram per day was associated with a rapid and reproducible fall in all Dane-particle markers in the three patients. The suppressive effect was transient when the interferon was given for 10 days or less but appeared to be more permanent when administration was prolonged for a month or more. In addition, long-term interferon therapy was associated with a marked fall in hepatitis B surface antigen in two of three patients and a disappearance of e antigen in two of two patients. Interferon may be useful in limiting carrier infectivity or eradicating chronic infection.
Authors:
H B Greenberg; R B Pollard; L I Lutwick; P B Gregory; W S Robinson; T C Merigan
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The New England journal of medicine     Volume:  295     ISSN:  0028-4793     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  1976 Sep 
Date Detail:
Created Date:  1976-10-02     Completed Date:  1976-10-02     Revised Date:  2009-10-27    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  517-22     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibodies, Viral / analysis
Chronic Disease
DNA Nucleotidyltransferases / blood
Drug Evaluation
Hepatitis B / blood,  enzymology,  therapy*
Hepatitis B Antigens / analysis
Hepatitis B virus / enzymology
Humans
Interferons / administration & dosage,  therapeutic use*
Leukocytes
Time Factors
Chemical
Reg. No./Substance:
0/Antibodies, Viral; 0/Hepatitis B Antigens; 9008-11-1/Interferons; EC 2.7.7.-/DNA Nucleotidyltransferases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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