Document Detail

Effect of human leukocyte interferon on HBsAg production in PLC/PRF/5 human hepatoma cell line.
MedLine Citation:
PMID:  2891279     Owner:  NLM     Status:  MEDLINE    
We describe the effect of the natural human interferon alfa (HuIFN alfa) on HBsAg production in PLC/PRF/5 cells. Decreased HBsAg production was regularly demonstrated 48 hr after the treatment of cells with 3-300 IU of HuIFN alfa/ml; it lasted for further 24-48 hr depending from the amount of interferon (IFN) added. We found no differences in the sensitivity to HuIFN alfa of non-confluent cells as compared to cells which had reached confluency. The decrease of the extracellular HBsAg excretion seems to be due to inhibition of intracellular HBsAg formation.
V Hajnická; D Stancek
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta virologica     Volume:  31     ISSN:  0001-723X     ISO Abbreviation:  Acta Virol.     Publication Date:  1987 Sep 
Date Detail:
Created Date:  1988-01-20     Completed Date:  1988-01-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370401     Medline TA:  Acta Virol     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  404-9     Citation Subset:  IM    
Research Institute of Preventive Medicine, Bratislava, Czechoslovakia.
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MeSH Terms
Antiviral Agents / pharmacology*
Carcinoma, Hepatocellular / microbiology,  pathology
Cell Line
Depression, Chemical
Gene Expression Regulation / drug effects
Hepatitis B Surface Antigens / biosynthesis*
Hepatitis B virus / drug effects
Interferon Type I / pharmacology*
Liver Neoplasms / microbiology,  pathology
Tumor Cells, Cultured / drug effects*,  metabolism,  microbiology
Reg. No./Substance:
0/Antiviral Agents; 0/Hepatitis B Surface Antigens; 0/Interferon Type I

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