| Effect of human chorionic gonadotropin before spermatic vessel ligation in the prepubertal rat testis. | |
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MedLine Citation:
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PMID: 7609167 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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After single stage Fowler-Stephens orchiopexy testicular atrophy is common. Previous experimental study in the scrotal testis of the adult rat has shown that ligation of the internal spermatic artery often causes focal testicular infarction or atrophy and exogenous human chorionic gonadotropin increases testicular blood flow. We questioned whether division of the internal spermatic artery in the undescended rat testis would also cause testicular injury and hypothesized that these changes might be prevented by administering human chorionic gonadotropin before vessel ligation. Two groups of 20-day-old Sprague-Dawley male rats were subjected to unilateral internal spermatic artery ligation. Group 1 (control) received no human chorionic gonadotropin, while group 2 received 10 IU human chorionic gonadotropin daily from days 3 to 17 of life. At 3 months testicular blood flow was quantitated using 141cerium radioactive microspheres. The results indicated that blood flow on the operated side was lower than on the nonoperated side but the change was not statistically significant. Human chorionic gonadotropin had no effect on blood flow to the operated testes. Gross testicular weights of operated versus nonoperated gonads were similar in rats that did and did not receive human chorionic gonadotropin. Pathological evaluation revealed normal histology in all testes. These results do not support the use of human chorionic gonadotropin preoperatively to stimulate collateral testicular blood flow. |
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Authors:
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D A Levy; F W Abdul-Karim; F Miraldi; J S Elder |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of urology Volume: 154 ISSN: 0022-5347 ISO Abbreviation: J. Urol. Publication Date: 1995 Aug |
Date Detail:
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Created Date: 1995-08-11 Completed Date: 1995-08-11 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0376374 Medline TA: J Urol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 738-40 Citation Subset: AIM; IM |
Affiliation:
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Department of Urology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Arteries Chorionic Gonadotropin / pharmacology* Ligation Male Preoperative Care Rats Rats, Sprague-Dawley Regional Blood Flow / drug effects Sexual Maturation Testis / blood supply*, drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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