Document Detail

Effect of hormones and antihormones on phospholipase A2 activity in human endometrial stromal cells.
MedLine Citation:
PMID:  8848549     Owner:  NLM     Status:  MEDLINE    
Phospholipase A2 activity was studied in isolated human endometrial predecidual cells, and in human endometrium collected from day 19-23 of the menstrual cycle, by performing a radiochemical assay. Phospholipase A2 activity on day 20 was significantly higher than other days (P < 0.001), and the activity was found to gradually decrease after day 20 of the menstrual cycle. The effects of the hormones estradiol and progesterone, and antihormones tamoxifen and RU 486, were studied on the phospholipase A2 activity in isolated predecidual stromal cells. Estradiol produced a significant stimulatory effect (P < 0.001) on phospholipase A2 activity in predecidual cells, and this effect was antagonized by tamoxifen. The combination of estradiol and tamoxifen was significantly different from estradiol alone (P < 0.001), but not from tamoxifen alone. RU 486 alone significantly increased (P < 0.001) phospholipase A2 activity in predecidual stromal cells. However, progesterone had no effect on phospholipase A2 activity in predecidual stromal cells.
S B Periwal; A Farooq; V L Bhargava; N Bhatla; U Vij; K Murugesan
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prostaglandins     Volume:  51     ISSN:  0090-6980     ISO Abbreviation:  Prostaglandins     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-10-24     Completed Date:  1996-10-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0320271     Medline TA:  Prostaglandins     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  191-201     Citation Subset:  IM    
Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi, India.
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MeSH Terms
Analysis of Variance
Endometrium / cytology,  drug effects*,  enzymology
Estradiol / pharmacology*
Estrogen Antagonists / pharmacology
Hormone Antagonists / pharmacology*
Mifepristone / pharmacology
Phospholipases A / drug effects*
Phospholipases A2
Progesterone / pharmacology*
Stromal Cells / drug effects
Tamoxifen / pharmacology
Reg. No./Substance:
0/Estrogen Antagonists; 0/Hormone Antagonists; 10540-29-1/Tamoxifen; 50-28-2/Estradiol; 57-83-0/Progesterone; 84371-65-3/Mifepristone; EC 3.1.1.-/Phospholipases A; EC A2

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