Document Detail


Effect of hormone replacement therapy on plasma lipoproteins and apolipoproteins, endothelial function and myocardial perfusion in postmenopausal women with estrogen receptor-alpha IVS1-397 C/C genotype and established coronary artery disease.
MedLine Citation:
PMID:  16612068     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Effect of hormone replacement (HRT) therapy on plasma lipoproteins and apolipoproteins, endothelial function and myocardial perfusion in postmenopausal women with estrogen receptor-alpha (ER-alpha) IVS1-397 C/C genotype and established coronary artery disease. BACKGROUND/AIMS: Associations between various ER-alpha polymorphisms and clinical phenotypes have been studied, including lipid levels and coronary atherosclerosis. We studied 48 postmenopausal women to determine the effect of ER-alpha IVS1-397 polymorphism on the response to treatment with HRT. METHODS: The study had a randomized, double-blind, placebo-controlled and crossover design. Patients were divided into two groups according to ER-alpha IVS1-397 polymorphism: CC genotype (n = 9); CT or TT genotype (n = 39). HRT was given continuously for 4 weeks, with 4-week washout periods between the treatment periods. Brachial artery Doppler and Tl-201 scintigraphy were performed at the end of each treatment period. RESULTS: HRT lowered total cholesterol, LDL-c and Apo-B levels from baseline values (all p < 0.05) and to a similar degree in CC and CT/TT genotype patients. HRT increased estradiol, HDL-c and Apo A-1 levels relative to baseline values, but to a greater degree in CC patients (p = 0.04, 0.05 and 0.04 by ANOVA, respectively). HRT increased peak forearm blood flow, brachial artery diameter during reactive hyperemia and endothelium-dependent dilation in both groups, but to a greater degree in CC patients (p = 0.03, 0.03 and 0.04 by ANOVA, respectively). Summed stress and rest scores were also more markedly reduced in CC patients (p = 0.04 and 0.05, respectively). The increase in estradiol levels was strongly correlated with the improvement in endothelium-dependent dilation (r = 0.66, p < 0.01), which in turn showed negative correlation with summed stress (r = -0.62, p < 0.01) and rest scores (r = -0.52, p < 0.05) in the CC genotype group. CONCLUSION: These data suggest that the improvement in endothelium-dependent dilation and the reduction in perfusion abnormalities by increasing estradiol levels with HRT in postmenopausal women with coronary artery disease may differ with respect to different genotypes, the effect being more prominent in those patients with ER-alpha IVS1-397 CC genotype.
Authors:
Ayse Emre; Sinan Sahin; Can Erzik; Zekeriya Nurkalem; Dilaver Oz; Beyazit Cirakoglu; Kemal Yesilcimen; Birsen Ersek
Related Documents :
3698268 - Association of apolipoprotein e polymorphism, low-density lipoprotein cholesterol, and ...
15882678 - Failure to achieve recommended ldl cholesterol levels by suboptimal statin therapy rela...
17375118 - Anti-inflammatory effect of virgin olive oil in stable coronary disease patients: a ran...
11724508 - Effects of low-density lipoprotein apheresis on coronary and carotid atherosclerosis an...
22685168 - Different expressions of adrenoceptors and grks in the human myocardium depend on heart...
23320478 - Direct somatic cell reprogramming: treatment of cardiac diseases.
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2006-04-10
Journal Detail:
Title:  Cardiology     Volume:  106     ISSN:  0008-6312     ISO Abbreviation:  Cardiology     Publication Date:  2006  
Date Detail:
Created Date:  2006-07-03     Completed Date:  2006-08-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  44-50     Citation Subset:  IM    
Copyright Information:
Copyright 2006 S. Karger AG, Basel
Affiliation:
Department of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Center, Istanbul, Turkey. aysesay@superonline.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Apolipoproteins / blood*
Brachial Artery / physiology
Coronary Artery Disease / blood,  genetics,  physiopathology
Cross-Over Studies
Double-Blind Method
Endothelium, Vascular / drug effects*
Estradiol / blood
Estrogen Receptor alpha / genetics*
Female
Genotype
Hormone Replacement Therapy*
Humans
Lipoproteins / blood*
Middle Aged
Polymorphism, Genetic
Postmenopause / blood,  drug effects*,  physiology
Progesterone / blood
Vasodilation / drug effects
Chemical
Reg. No./Substance:
0/Apolipoproteins; 0/Estrogen Receptor alpha; 0/Lipoproteins; 50-28-2/Estradiol; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Differential densities of muscarinic acetylcholine receptor and I(K,ACh) in canine supraventricular ...
Next Document:  Coronary artery bypass grafting is associated with a significant worsening of QT dynamicity and hear...