| Effect of hormone replacement therapy on clitoral artery blood flow in healthy postmenopausal women. | |
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MedLine Citation:
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PMID: 18547387 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Aging and the decline of ovarian hormonal secretion during menopause may alter libido, and sexual response and functioning. The effects of hormone replacement therapy (HRT) on the genital vascular hemodynamics have been widely studied. However, there is a lack of knowledge about the effect of HRT on basal clitoral blood flow. AIM: The aims of this study were to measure clitoral artery blood flow and to determine whether HRT has a significant effect in clitoral artery blood flow in postmenopausal women. METHODS: Doppler sonography of clitoral arteries was performed in 25 postmenopausal women aged 51.3 +/- 4.5 years who had been using a continuous combined HRT (0.625 mg of conjugated equine estrogens plus 2.5 mg medroxyprogesterone acetate, in 1 tablet daily) for 2.0 +/- 1.1 years, and the clitoral artery peak systolic velocity, resistance index (RI), and pulsatility index (PI) were measured. Thirty-five postmenopausal women aged 50.0 +/- 4.2 years who had not used HRT served as a control group. MAIN OUTCOME MEASURES: Assessment of clitoral blood flow with color Doppler ultrasonography by measuring the peak systolic velocity, RI, and PI. RESULTS: Clitoral artery circulation was easily detectable by the color Doppler sonography. The clitoral artery peak systolic velocities were significantly higher in postmenopausal women taking HRT compared with the control group (11.8 +/- 5.2 cm/second vs. 15.0 +/- 5.4 cm/second, P = 0.025). CONCLUSION: HRT improves blood flow to the clitoris. A clitoral blood flow evaluation may be proposed as a potential tool to assess the impact of HRT on the genital tissues and to investigate female sexual response disorders in postmenopausal women. |
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Authors:
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Erkan Alatas; Baki Yagci; Ozer Oztekin; Nuran Sabir |
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Publication Detail:
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Type: Journal Article Date: 2008-06-10 |
Journal Detail:
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Title: The journal of sexual medicine Volume: 5 ISSN: 1743-6109 ISO Abbreviation: - Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-11-14 Completed Date: 2009-04-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101230693 Medline TA: J Sex Med Country: United States |
Other Details:
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Languages: eng Pagination: 2367-73 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Pamukkale University Medical Faculty, Denizli, Turkey. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aging / metabolism, physiology Clitoris / blood supply*, ultrasonography Cross-Sectional Studies Estrogen Replacement Therapy* Female Hemodynamics Humans Middle Aged Prospective Studies Sexual Dysfunctions, Psychological / drug therapy, prevention & control Ultrasonography, Doppler, Color |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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