Document Detail

Effect of a homologous series of halogenated methanes on pulmonary uptake of 5-hydroxytryptamine in isolated perfused rat lung.
MedLine Citation:
PMID:  4083038     Owner:  NLM     Status:  MEDLINE    
The potency of halogenated methanes to inhibit uptake of 5-hydroxytryptamine (5-HT) from the pulmonary circulation was studied using an isolated, perfused and ventilated rat lung preparation. The agents were vaporized and mixed with the inlet air. The results indicate that the degree of chlorination is the most important factor for potency of the methanes to inhibit lung uptake of 5-HT. When hydrogen was substituted with fluorine the potency was decreased dramatically. Bromine seemed to have the opposite effect. The data also suggested that the degree of chlorination was more important rather than hydrophobic/hydrophilic balance of the solvent molecule. These effects seem to be correlated with the narcotic effects of the substances studied.
A R Hede; L Andersson; C Post
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta pharmacologica et toxicologica     Volume:  57     ISSN:  0001-6683     ISO Abbreviation:  Acta Pharmacol Toxicol (Copenh)     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1986-02-14     Completed Date:  1986-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370572     Medline TA:  Acta Pharmacol Toxicol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  291-6     Citation Subset:  IM    
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MeSH Terms
Hydrocarbons, Halogenated / pharmacology*
Lung / drug effects,  metabolism*
Methane / analogs & derivatives,  pharmacology
Rats, Inbred Strains
Serotonin / metabolism*
Structure-Activity Relationship
Time Factors
Reg. No./Substance:
0/Hydrocarbons, Halogenated; 50-67-9/Serotonin; 74-82-8/Methane

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