Document Detail

Effect of histone H1 on estrogen receptor status of human breast cancer MCF 7 cells.
MedLine Citation:
PMID:  16010982     Owner:  NLM     Status:  MEDLINE    
The effects of exogenous histone H1 on estrogen receptor status of human breast cancer MCF 7 cells were investigated in presence and absence of estrogen. Exogenous histone H1 was significantly cytotoxic in a dose- and time-dependent manner. Cell cycle analysis revealed a significant increase in the percentage of cell accumulation in G0/G1 phase. In histone H1-treated cells, a significant decrease in the estrogen receptor content and an increase in the dissociation constant (KD) of ER was observed compared to control.
G Vani; C S Shyamala Devi
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  272     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-07-13     Completed Date:  2005-10-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  151-5     Citation Subset:  IM    
Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India.
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MeSH Terms
Breast Neoplasms / metabolism*
Cell Cycle / drug effects
Estradiol / pharmacology
Estrogen Antagonists / pharmacology*
Histones / pharmacology*
Receptors, Estrogen / metabolism*
Tumor Cells, Cultured
Tumor Stem Cell Assay
Reg. No./Substance:
0/Estrogen Antagonists; 0/Histones; 0/Receptors, Estrogen; 50-28-2/Estradiol

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