Document Detail


Effect of histone H1 on estrogen receptor status of human breast cancer MCF 7 cells.
MedLine Citation:
PMID:  16010982     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of exogenous histone H1 on estrogen receptor status of human breast cancer MCF 7 cells were investigated in presence and absence of estrogen. Exogenous histone H1 was significantly cytotoxic in a dose- and time-dependent manner. Cell cycle analysis revealed a significant increase in the percentage of cell accumulation in G0/G1 phase. In histone H1-treated cells, a significant decrease in the estrogen receptor content and an increase in the dissociation constant (KD) of ER was observed compared to control.
Authors:
G Vani; C S Shyamala Devi
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  272     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-07-13     Completed Date:  2005-10-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  151-5     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India. vangan@yahoo.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Breast Neoplasms / metabolism*
Cell Cycle / drug effects
Estradiol / pharmacology
Estrogen Antagonists / pharmacology*
Female
Histones / pharmacology*
Humans
Receptors, Estrogen / metabolism*
Tumor Cells, Cultured
Tumor Stem Cell Assay
Chemical
Reg. No./Substance:
0/Estrogen Antagonists; 0/Histones; 0/Receptors, Estrogen; 50-28-2/Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Regulation of high molecular weight bovine brain neutral protease by phospholipids in vitro.
Next Document:  Amelioration of diabetic dyslipidemia by macrocyclic binuclear oxovanadium complex on streptozotocin...