| Effect of histamine H2-receptor antagonists on vitamin B12 absorption. | |
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MedLine Citation:
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PMID: 1358279 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To discuss the potential of histamine H2-receptor antagonists (H2RAs) to cause malabsorption of vitamin B12 (cyanocobalamin). DATA SOURCES: Pertinent literature was identified via a MEDLINE search. Journals and references cited in published articles also were used as data sources. STUDY SELECTION: Studies evaluating the effect of H2RAs on vitamin B12 absorption were reviewed. DATA SYNTHESIS: H2RAs decrease acid secretion by the gastric parietal cells. Gastric acid and pepsin produced by these cells are required for the cleavage of vitamin B12 from dietary sources. Intrinsic factor (IF), also produced by gastric parietal cells, is required for vitamin B12 absorption from the gastrointestinal tract. Although H2RAs have not conclusively been shown to decrease IF secretion, studies have demonstrated a significant reduction in food-bound vitamin B12 absorption secondary to decreased acid secretion in patients taking these drugs. CONCLUSIONS: H2RAs have the potential to cause vitamin B12 deficiency. This may be important in patients with inadequate stores of vitamin B12 (e.g., poor diet), particularly those receiving H2RA therapy continuously for more than two years. Healthcare providers should be aware of this potential adverse effect. |
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Authors:
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R W Force; M C Nahata |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Annals of pharmacotherapy Volume: 26 ISSN: 1060-0280 ISO Abbreviation: Ann Pharmacother Publication Date: 1992 Oct |
Date Detail:
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Created Date: 1992-12-16 Completed Date: 1992-12-16 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9203131 Medline TA: Ann Pharmacother Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1283-6 Citation Subset: IM |
Affiliation:
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College of Pharmacy, Ohio State University, Columbus 43210. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cimetidine
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therapeutic use Clinical Trials as Topic Histamine H2 Antagonists / pharmacology*, therapeutic use Humans Intestinal Absorption / drug effects* Peptic Ulcer / physiopathology, therapy Ranitidine / therapeutic use Vitamin B 12 / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Histamine H2 Antagonists; 51481-61-9/Cimetidine; 66357-35-5/Ranitidine; 68-19-9/Vitamin B 12 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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