| Effect of a histamine H2-receptor antagonist, famotidine, on gastric secretion in healthy subjects. | |
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MedLine Citation:
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PMID: 2889528 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of 20 mg of famotidine or placebo on secretion of gastric juice and gastric acid were studied in ten healthy subjects in a randomized, crossover study. Gastric juice was aspirated and collected at hourly intervals for 24 hours after oral administration, and acid output was calculated based on gastric juice output and acid concentration. Secretion of gastric juice and acid output were lower after famotidine was administered than after placebo; over the 12-hour post-administration period, the hourly acid concentrations were significantly lower after famotidine than after placebo. During the 12 hours after famotidine or placebo, gastric juice output was 180.7 +/- 32.1 ml (mean +/- SE) in the placebo group and 64.7 +/- 9.1 ml in the famotidine group (P less than 0.01); acid concentrations were 49.3 +/- 3.8 mmol/L in the placebo group and 9.6 +/- 3.1 mmol/L in the famotidine group (P less than 0.01); acid output was 8.89 +/- 1.59 mmol in the placebo group and 0.55 +/- 0.17 mmol in the famotidine group (P less than 0.01). These results support the effectiveness of a 12 hour or possibly a 24-hour dosing interval for famotidine. |
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Authors:
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Y Fukuda; I Ikezoe; M Okabayashi; I Ohama; T Shimoyama |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Clinical therapeutics Volume: 9 ISSN: 0149-2918 ISO Abbreviation: Clin Ther Publication Date: 1987 |
Date Detail:
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Created Date: 1987-12-17 Completed Date: 1987-12-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7706726 Medline TA: Clin Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 528-35 Citation Subset: IM |
Affiliation:
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Hyogo College of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Famotidine Gastric Acid / secretion* Gastric Juice / secretion* Histamine H2 Antagonists / pharmacology* Humans Male Random Allocation Thiazoles / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Histamine H2 Antagonists; 0/Thiazoles; 76824-35-6/Famotidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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