Document Detail


Effect of highly active antiretroviral therapy on cytomegalovirus antigenaemia in AIDS patients.
MedLine Citation:
PMID:  11319974     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To assess the effect of highly active antiretroviral therapy (HAART) on cytomegalovirus (CMV) antigenaemia in AIDS patients, 70 patients with CD4+ cell counts < or = 50/mm3 and positive anti-(CMV) immunoglobulin G (IgG) were tested at 15-30 day intervals for CMV antigenaemia. We selected those patients who had been followed up for more than 3 months. Three patient profiles were defined: A, followed up before the introduction of HAART; B, followed up before and after the use of HAART; and C, followed up after the use of HAART. Thirty-nine patients were included, 12 in group A, 17 in group B, and 10 in group C. Group A patients presented a lower median CD4+ cell count compared with groups B and C patients (9, 122 and 127 cells/mm3, respectively), with the increase in the last 2 groups being related to the use of HAART (P<0.001). A lower proportion of positive antigenaemia was observed in group B after the introduction of HAART compared with the time before HAART (P=0.02). HAART caused an immunological improvement and was found to be associated with negativity of CMV antigenaemia.
Authors:
L H Borges; L S Villas Boas; S H Warren-Santoro; M P Estevam; D E Uip; C Savalli; M Curi; C S Pannuti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of STD & AIDS     Volume:  12     ISSN:  0956-4624     ISO Abbreviation:  Int J STD AIDS     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-26     Completed Date:  2001-12-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9007917     Medline TA:  Int J STD AIDS     Country:  England    
Other Details:
Languages:  eng     Pagination:  234-8     Citation Subset:  IM; X    
Affiliation:
AIDS Clinic, Instituto de Medicina Tropical de São Paulo, Department of Infectious Diseases, University of São Paulo School of Medicine, São Paulo, Brazil. lhborges.vix@zaz.com.br
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MeSH Terms
Descriptor/Qualifier:
AIDS-Related Opportunistic Infections / drug therapy*
Adult
Anti-HIV Agents / pharmacology,  therapeutic use*
Antigens, Viral / blood*
Antiretroviral Therapy, Highly Active*
CD4 Lymphocyte Count
Cytomegalovirus / drug effects*,  growth & development,  immunology
Cytomegalovirus Infections / drug therapy*,  immunology
Cytomegalovirus Retinitis / drug therapy,  immunology
Female
HIV Seropositivity / complications,  drug therapy
Humans
Male
Middle Aged
Viral Load
Viremia / drug therapy,  immunology
Chemical
Reg. No./Substance:
0/Anti-HIV Agents; 0/Antigens, Viral

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