| Effect of a high or low ambient perinatal temperature on adult obesity in Osborne-Mendel and S5B/Pl rats. | |
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MedLine Citation:
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PMID: 15677528 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Perinatal environment is an important determinant of health status of adults. We tested the hypothesis that perinatal ambient temperature alters sympathetic activity and affects body composition in adult life and that this effect differs between S5B/Pl (S5B) and Osborne-Mendel (OM) strains of rat that were resistant (S5B) or susceptible (OM) to dietary obesity. From 1 wk before birth, rat litters were raised at either 18 or 30 degrees C until 2 mo of age while consuming a chow diet. Rats were then housed at normal housing temperature (22 degrees C) and provided either high-fat or low-fat diet. OM rats initially reared at 18 degrees C gained more weight on both diets than those reared at 30 degrees C. Perinatal temperature had no effect on body weight gain of the S5B rats on either diet. At 12 wk of age, OM and S5B rats reared at 18 degrees C had higher intakes of the high-fat diet than those reared at 30 degrees C but lower beta3-adrenergic receptor (beta3-AR) and uncoupling protein-1 (UCP1) mRNA levels in brown adipose tissue (BAT). The increase in metabolic rate in response to the beta3-agonist CL-316243, was greater in both OM and S5B rats reared at 18 degrees C than in those reared at 30 degrees C. Perinatal temperature differentially affects body weight in OM and S5B rats while having similar effects on food intake, response to a beta3-agonist, and BAT beta3-AR and UCP-1. The data suggest that OM rats are more susceptible to epigenetic programming than S5B rats. |
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Authors:
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Christy L White; H Doug Braymer; David A York; George A Bray |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. Date: 2005-01-27 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 288 ISSN: 0363-6119 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-04-11 Completed Date: 2005-05-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
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Languages: eng Pagination: R1376-84 Citation Subset: IM |
Affiliation:
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Pennington Biomedical Research Center, Louisiana State Univ. System, 6400 Perkins Road, Baton Rouge, LA 70808, USA. whitecl@pbrc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue, Brown
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physiology Aging Animals Animals, Newborn / physiology* Basal Metabolism / drug effects Dietary Fats Dioxoles / pharmacology Energy Metabolism Female Gene Expression Regulation / physiology Obesity / embryology, physiopathology* Pregnancy Prenatal Exposure Delayed Effects* Rats Rats, Inbred Strains Temperature* |
| Grant Support | |
ID/Acronym/Agency:
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DK-10151-02/DK/NIDDK NIH HHS; R01 DK-32089/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Dioxoles; 138908-40-4/CL 316243 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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