Document Detail

Effect of high hematocrit and high blood flow rates on transmembrane pressure and ultrafiltration rate in hemodialysis.
MedLine Citation:
PMID:  1801859     Owner:  NLM     Status:  MEDLINE    
Removal of prescribed ultrafiltration volumes in hemodialysis requires knowledge of both the ultrafiltration coefficient of the dialyzer and the average transmembrane pressure (TMP) in the dialyzer. While it has been a fairly common practice to assume that the TMP is constant along the length of the dialyzer, it actually decreases linearly from a maximum value at the blood inlet to a minimum value at the blood outlet. In the past, ignoring the difference between arterial and venous TMPs when calculating the dialysate pressure setting did not result in significant errors in ultrafiltration volume. However, with the introduction of erythropoietin therapy and the trend toward high-efficiency dialysis, increases in hematocrit and blood flow rate have led to axial variations in TMP which, if ignored, can lead to inaccurate fluid removal. The goals of this paper are to provide an understanding of how high hematocrits and high blood flow rates affect TMP and ultrafiltration rate, and to provide simple guidelines for ensuring accurate fluid removal. Sample calculations are given on the last page for easy reference.
N J Ofsthun; J C Jensen; M Kray
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Blood purification     Volume:  9     ISSN:  0253-5068     ISO Abbreviation:  Blood Purif.     Publication Date:  1991  
Date Detail:
Created Date:  1992-04-28     Completed Date:  1992-04-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8402040     Medline TA:  Blood Purif     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  169-76     Citation Subset:  IM    
Renal Division, Baxter Healthcare, Round Lake, Ill.
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MeSH Terms
Blood Flow Velocity*
Erythropoietin / pharmacology,  therapeutic use
Kidney Failure, Chronic / physiopathology*,  therapy
Renal Dialysis*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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