| Effect of high hematocrit and high blood flow rates on transmembrane pressure and ultrafiltration rate in hemodialysis. | |
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MedLine Citation:
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PMID: 1801859 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Removal of prescribed ultrafiltration volumes in hemodialysis requires knowledge of both the ultrafiltration coefficient of the dialyzer and the average transmembrane pressure (TMP) in the dialyzer. While it has been a fairly common practice to assume that the TMP is constant along the length of the dialyzer, it actually decreases linearly from a maximum value at the blood inlet to a minimum value at the blood outlet. In the past, ignoring the difference between arterial and venous TMPs when calculating the dialysate pressure setting did not result in significant errors in ultrafiltration volume. However, with the introduction of erythropoietin therapy and the trend toward high-efficiency dialysis, increases in hematocrit and blood flow rate have led to axial variations in TMP which, if ignored, can lead to inaccurate fluid removal. The goals of this paper are to provide an understanding of how high hematocrits and high blood flow rates affect TMP and ultrafiltration rate, and to provide simple guidelines for ensuring accurate fluid removal. Sample calculations are given on the last page for easy reference. |
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Authors:
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N J Ofsthun; J C Jensen; M Kray |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Blood purification Volume: 9 ISSN: 0253-5068 ISO Abbreviation: Blood Purif. Publication Date: 1991 |
Date Detail:
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Created Date: 1992-04-28 Completed Date: 1992-04-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8402040 Medline TA: Blood Purif Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 169-76 Citation Subset: IM |
Affiliation:
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Renal Division, Baxter Healthcare, Round Lake, Ill. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Flow Velocity* Erythropoietin / pharmacology, therapeutic use Hematocrit* Humans Kidney Failure, Chronic / physiopathology*, therapy Kinetics Pressure Renal Dialysis* Ultrafiltration |
| Chemical | |
Reg. No./Substance:
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11096-26-7/Erythropoietin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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