Document Detail


Effect of high-frequency oscillation on gas exchange and pulmonary phospholipids in experimental hyaline membrane disease.
MedLine Citation:
PMID:  6342479     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Arterial PO2 and PCO2 obtained with 2 modes of mechanical ventilation were compared in 5 premature monkeys with hyaline membrane disease (HMD) during the first 7 h of life. High-frequency oscillation (HFO) (10 Hertz) was compared with conventional positive-pressure ventilation (CMV) by matching the mean airway pressure generated by the 2 systems. Each animal served as its own control; HFO sustained an improved PaCO2 (39 +/- 8 versus 25 +/- 7 mmHg). An insignificant improvement in arterial PO2 was noted. The improved CO2 exchange occurred with a lower peak airway pressure (35 +/- 4 versus 23 +/- 11 cm H2O). Comparison of the postmortem pressure-volume curves and lung and lavage phospholipid concentrations from the animals treated with HFO in the current study to a matched set of animals treated exclusively with CMV in a previous study failed to reveal any differences. We conclude that HFO is effective in eliminating CO2 in experimental HMD without apparently altering lung biochemical or mechanical properties in a manner different from that found with CMV.
Authors:
W E Truog; T A Standaert; J Murphy; S Palmer; D E Woodrum; W A Hodson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  127     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1983 May 
Date Detail:
Created Date:  1983-06-17     Completed Date:  1983-06-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  585-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn*
Blood Gas Analysis
Humans
Hyaline Membrane Disease / physiopathology,  therapy*
Infant, Newborn
Irrigation
Lung / analysis
Macaca nemestrina
Phosphatidylcholines / analysis
Phospholipids / analysis
Positive-Pressure Respiration*
Pulmonary Gas Exchange
Respiration, Artificial*
Grant Support
ID/Acronym/Agency:
HL-19187/HL/NHLBI NIH HHS; HL-26994/HL/NHLBI NIH HHS; RR-00166/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Phosphatidylcholines; 0/Phospholipids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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