| Effect of high-fat diet on stress responsiveness in borderline hypertensive rats. | |
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MedLine Citation:
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PMID: 20666663 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Stress in combination with genetic susceptibility is a factor in the development of hypertension. We used borderline hypertensive rats to investigate whether exposure to high-fat and/or junk-food diet at different stages of ontogeny has programing consequences on stress responses. Wistar dams were fed a high- or low-fat diet for 6 weeks prior to mating with spontaneously hypertensive males, and during gestation. At birth, litters were fostered either to a dam in the same or an alternative diet condition as during gestation. After weaning, male offspring were fed either a control-chow diet or an intermittent junk food fatty diet. Between postnatal days 57-61, half of the rats in each dietary group received daily social defeat sessions using a resident-intruder protocol, and the other half were unstressed controls. Blood pressure was measured indirectly both before and after each defeat session. On the final day, rats were killed for physiological measures. Socially defeated rats showed large increases in serum corticosterone concentration and adrenal hypertrophy, indicating the effectiveness of this non-adapting stressor. Serum corticosterone level was also higher in rats fed with the junk-food diet post-weaning compared with those fed with chow only, but there were no significant effects of gestational or lactational dietary history. |
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Authors:
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A Mitra; E M Crump; K M Alvers; K L Robertson; N E Rowland |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-07-28 |
Journal Detail:
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Title: Stress (Amsterdam, Netherlands) Volume: 14 ISSN: 1607-8888 ISO Abbreviation: Stress Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9617529 Medline TA: Stress Country: England |
Other Details:
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Languages: eng Pagination: 42-52 Citation Subset: IM |
Affiliation:
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Department of Psychology, University of Florida, Gainesville, FL, 32611-2250, USA. amitra@umn.edu |
Export Citation:
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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DK064712/DK/NIDDK NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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