Document Detail

Effect of high dose vitamin C supplementation on muscle soreness, damage, function, and oxidative stress to eccentric exercise.
MedLine Citation:
PMID:  16948483     Owner:  NLM     Status:  MEDLINE    
This study investigated if vitamin C supplementation before and after eccentric exercise could reduce muscle soreness (MS), oxidative stress, and muscle function. Eighteen healthy men randomly assigned to either a placebo (P) or vitamin C (VC) (3 g/d) treatment group took pills for 2 wk prior and 4 d after performing 70 eccentric elbow extensions with their non-dominant arm. MS increased in both groups with significantly reduced MS for the first 24 h with VC. Range of motion was reduced equally in both groups after the exercise (P > or = 0.05). Muscle force declined equally and was unaffected by treatment. VC attenuated the creatine kinase (CK) increase at 48 h after exercise with similar CK after this time. Glutathione ratio (oxidized glutathione/total glutathione) was significantly increased at 4 and 24 h with P but VC prevented this change. These data suggest that vitamin C pretreatment can reduce MS, delay CK increase, and prevent blood glutathione oxidation with little influence on muscle function loss.
S C Bryer; A H Goldfarb
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  International journal of sport nutrition and exercise metabolism     Volume:  16     ISSN:  1526-484X     ISO Abbreviation:  Int J Sport Nutr Exerc Metab     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-09-04     Completed Date:  2006-10-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100939812     Medline TA:  Int J Sport Nutr Exerc Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  270-80     Citation Subset:  IM    
Exercise and Sport Science Dept, University of North Carolina Greensboro, 27402-6170, USA.
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MeSH Terms
Antioxidants / administration & dosage,  pharmacology*
Ascorbic Acid / administration & dosage,  pharmacology*
Creatine Kinase / analysis,  blood
Dietary Supplements
Exercise / physiology*
Glutathione / analysis,  metabolism
Muscle Contraction / drug effects,  physiology
Muscle, Skeletal / drug effects*,  physiology*
Oxidative Stress / drug effects*,  physiology
Pain / metabolism
Time Factors
Reg. No./Substance:
0/Antioxidants; 50-81-7/Ascorbic Acid; 70-18-8/Glutathione; EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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