| Effect of high dose vitamin C supplementation on muscle soreness, damage, function, and oxidative stress to eccentric exercise. | |
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MedLine Citation:
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PMID: 16948483 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study investigated if vitamin C supplementation before and after eccentric exercise could reduce muscle soreness (MS), oxidative stress, and muscle function. Eighteen healthy men randomly assigned to either a placebo (P) or vitamin C (VC) (3 g/d) treatment group took pills for 2 wk prior and 4 d after performing 70 eccentric elbow extensions with their non-dominant arm. MS increased in both groups with significantly reduced MS for the first 24 h with VC. Range of motion was reduced equally in both groups after the exercise (P > or = 0.05). Muscle force declined equally and was unaffected by treatment. VC attenuated the creatine kinase (CK) increase at 48 h after exercise with similar CK after this time. Glutathione ratio (oxidized glutathione/total glutathione) was significantly increased at 4 and 24 h with P but VC prevented this change. These data suggest that vitamin C pretreatment can reduce MS, delay CK increase, and prevent blood glutathione oxidation with little influence on muscle function loss. |
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Authors:
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S C Bryer; A H Goldfarb |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: International journal of sport nutrition and exercise metabolism Volume: 16 ISSN: 1526-484X ISO Abbreviation: Int J Sport Nutr Exerc Metab Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-09-04 Completed Date: 2006-10-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100939812 Medline TA: Int J Sport Nutr Exerc Metab Country: United States |
Other Details:
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Languages: eng Pagination: 270-80 Citation Subset: IM |
Affiliation:
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Exercise and Sport Science Dept, University of North Carolina Greensboro, 27402-6170, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antioxidants / administration & dosage, pharmacology* Ascorbic Acid / administration & dosage, pharmacology* Creatine Kinase / analysis, blood Dietary Supplements Exercise / physiology* Glutathione / analysis, metabolism Humans Male Muscle Contraction / drug effects, physiology Muscle, Skeletal / drug effects*, physiology* Oxidation-Reduction Oxidative Stress / drug effects*, physiology Pain / metabolism Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 50-81-7/Ascorbic Acid; 70-18-8/Glutathione; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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