Document Detail


Effect of high-dose methylprednisolone and G-CSF treatments on lymphocyte subtypes in neutropenic children with acute lymphoblastic leukemia: a pilot study.
MedLine Citation:
PMID:  9842648     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Treatment of neutropenia with corticosteroids and hemopoietic growth factors may cause alterations in the immune system. This study investigated and compared the effects of various regimens (HDMP, G-CSF, and G-CSF + HDMP) on total lymphocyte counts and subtypes in neutropenic patients with acute lymphoblastic leukemia. Lymphocyte subtypes were studied just prior to treatment and 1 week later. In the HDMP group, total lymphocyte counts and the numbers of CD3+, CD4+, CD8+, and CD19+ lymphocytes and monocytes increased, while the helper/suppressor lymphocyte ratio decreased. No significant changes were seen in lymphocyte subtypes in the G-CSF and G-CSF + HDMP groups, apart from an increase in total lymphocyte numbers. In the control group there was an increase in the number of CD3+ and CD8+ lymphocytes and a decrease in the helper/suppressor lymphocyte ratio. These results suggest that HDMP has an inducing, rather than a suppressive effect on all lymphocyte subtypes studied.
Authors:
N Ozbek; S Yetgin; A M Tuncer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric hematology and oncology     Volume:  15     ISSN:  0888-0018     ISO Abbreviation:  Pediatr Hematol Oncol     Publication Date:    1998 Nov-Dec
Date Detail:
Created Date:  1999-02-16     Completed Date:  1999-02-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8700164     Medline TA:  Pediatr Hematol Oncol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  539-44     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, School of Medicine, Başkent University, Ankara, Turkey. nozbek@neuron.ato.org.tr
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Anti-Inflammatory Agents / administration & dosage*
Antigens, CD
Child
Child, Preschool
Granulocyte Colony-Stimulating Factor / administration & dosage*
Humans
Immunophenotyping
Lymphocyte Subsets / drug effects*,  immunology
Methylprednisolone / administration & dosage*
Neutropenia / blood,  drug therapy*,  immunology
Precursor Cell Lymphoblastic Leukemia-Lymphoma / blood,  drug therapy*,  immunology
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Antigens, CD; 143011-72-7/Granulocyte Colony-Stimulating Factor; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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