| Effect of high dose growth hormone with glutamine and no change in diet on intestinal absorption in short bowel patients: a randomised, double blind, crossover, placebo controlled study. | |
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MedLine Citation:
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PMID: 10896910 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: High dose growth hormone, glutamine, and a high carbohydrate diet may improve intestinal function in short bowel patients. AIMS: To investigate if growth hormone with glutamine and no change in diet improved intestinal function. PATIENTS AND METHODS: Eight short bowel patients were randomised in a double blind crossover study between placebo and growth hormone (mean 0.12 mg/kg/day) with oral (mean 28 g/day) and parenteral glutamine (mean 5.2 g/day) for 28 days. Balance studies were performed at baseline and five days after placebo and treatment were terminated. Dietary energy, carbohydrate, and fat were maintained as usual. RESULTS: Growth hormone with glutamine did not improve intestinal absorption of energy (baseline, placebo, treatment, mean: 46%, 48%, 46% of oral intake, respectively), carbohydrate (71%, 70%, 71%), fat (20%, 15%, 18%), nitrogen (27%, 18%, 19%), wet weight (37%, 39%, 31%), sodium (-16%, -16%, -36%), potassium (43%, 47%, 33%), calcium (-16%, -16%, -15%) or magnesium (-3%, 4%, 2%) compared with placebo or baseline (p>0.05) five days after treatment was terminated. All patients experienced adverse effects. CONCLUSIONS: Combined high dose growth hormone and glutamine administered for four weeks did not improve intestinal absorption five days after treatment was terminated in short bowel patients on their usual diet. |
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Authors:
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J Szkudlarek; P B Jeppesen; P B Mortensen |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Gut Volume: 47 ISSN: 0017-5749 ISO Abbreviation: Gut Publication Date: 2000 Aug |
Date Detail:
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Created Date: 2000-08-18 Completed Date: 2000-08-18 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2985108R Medline TA: Gut Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 199-205 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Section of Gastroenterology, Rigshospitalet, University of Copenhagen, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cross-Over Studies Diet* Double-Blind Method Female Glutamine / administration & dosage, therapeutic use* Growth Hormone / therapeutic use* Humans Intestinal Absorption / drug effects* Male Middle Aged Short Bowel Syndrome / drug therapy* Treatment Outcome Water-Electrolyte Imbalance / chemically induced Weight Gain / drug effects |
| Chemical | |
Reg. No./Substance:
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56-85-9/Glutamine; 9002-72-6/Growth Hormone |
| Comments/Corrections | |
Comment In:
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Gut. 2000 Aug;47(2):164
[PMID:
10896902
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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