Document Detail

Effect of high-dose fentanyl on renal function in dogs.
MedLine Citation:
PMID:  9532845     Owner:  NLM     Status:  MEDLINE    
Our objective was to determine the effects of high-dose fentanyl on canine renal function (RF). We anesthetized with sodium pentobarbital (SP) 16 dogs, randomly divided into 2 groups: in G1, SP was given alone, and in G2, combined with 0.05 fentanyl. All animals were ventilated artificially and had catheterized left and right femoral veins and left femoral artery for fluid infusion, drug administration, blood collection, and hemodynamic measurement. Urine was collected throughout the experiment. Attributes of RF were studied. SP did not alter RF, which was significantly altered by fentanyl. In G2, slower heart rates, mean arterial pressure, creatinine clearance, urinary output, osmolar clearance and fractional excretion of sodium and potassium were observed. G1 had a behavior attributed to extracellular volume expansion and no RF alterations. In G2, we observed significant decreases in RF due to opioid-induced hemodynamic changes, not discarding the possible action of aldosterone.
Y M Castiglia; J R Braz; P T Vianna; L Lemonica; L A Vane
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  São Paulo medical journal = Revista paulista de medicina     Volume:  115     ISSN:  1516-3180     ISO Abbreviation:  Sao Paulo Med J     Publication Date:    1997 May-Jun
Date Detail:
Created Date:  1998-06-15     Completed Date:  1998-06-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100897261     Medline TA:  Sao Paulo Med J     Country:  BRAZIL    
Other Details:
Languages:  eng     Pagination:  1433-9     Citation Subset:  IM    
Departamento de Anestesiologia da Faculdade de Medicina de Botucatu-UNESP-São Paulo, Brazil.
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MeSH Terms
Adjuvants, Anesthesia / pharmacology*
Fentanyl / pharmacology*
Heart Rate / drug effects
Hemodynamics / drug effects
Hypnotics and Sedatives / pharmacology
Kidney / drug effects*
Kidney Function Tests
Pentobarbital / pharmacology
Time Factors
Reg. No./Substance:
0/Adjuvants, Anesthesia; 0/Hypnotics and Sedatives; 437-38-7/Fentanyl; 76-74-4/Pentobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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